Plasmodium kinases as targets for new-generation antimalarials (Q38066993)

28 August 2017

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title

Plasmodium kinases as targets for new-generation antimalarials (English)

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28 August 2017

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David Drewry

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Christian Doerig

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Isabelle S Lucet

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28 August 2017

Andrew Tobin

series ordinal

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28 August 2017

Andrew F Wilks

series ordinal

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28 August 2017

publication date

1 December 2012

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Future Medicinal Chemistry

28 August 2017

published in

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28 August 2017

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28 August 2017

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28 August 2017

page(s)

2295-2310

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How malaria has affected the human genome and what human genetics can teach us about malaria

28 August 2017

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Microbiology. Is the tide turning for new malaria medicines?

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Back to the future: lessons learned in modern target-based and whole-cell lead optimization of antimalarials.

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How were new medicines discovered?

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Thousands of chemical starting points for antimalarial lead identification

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Targeting cancer with small molecule kinase inhibitors

21 January 2018

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Assessment of chemical coverage of kinome space and its implications for kinase drug discovery.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.183

Comprehensive analysis of kinase inhibitor selectivity

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.183

Purification and molecular characterization of cGMP-dependent protein kinase from Apicomplexan parasites. A novel chemotherapeutic target

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.183

The role of cGMP signalling in regulating life cycle progression of Plasmodium

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.183

Tinkering Outside the Kinase ATP Box: Allosteric (Type IV) and Bivalent (Type V) Inhibitors of Protein Kinases

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.183

A genomic perspective of protein kinases in Plasmodium falciparum

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.183

Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.183

Malaria: targeting parasite and host cell kinomes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Disruption of the PfPK7 gene impairs schizogony and sporogony in the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Genomic analysis of the eukaryotic protein kinase superfamily: a perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

A new Apicomplexa-specific protein kinase family: multiple members in Plasmodium falciparum, all with an export signature

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

The kinomes of apicomplexan parasites

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.183

The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.183

Exploring the Plasmodium falciparum cyclic-adenosine monophosphate (cAMP)-dependent protein kinase (PfPKA) as a therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.183

Characterization of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG): antiparasitic activity of a PKG inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Role of Ca2+/calmodulin-PfPKB signaling pathway in erythrocyte invasion by Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

PfPKB, a protein kinase B-like enzyme from Plasmodium falciparum: II. Identification of calcium/calmodulin as its upstream activator and dissection of a novel signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

PfPKB, a novel protein kinase B-like enzyme from Plasmodium falciparum: I. Identification, characterization, and possible role in parasite development

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Regulation of Plasmodium falciparum glideosome associated protein 45 (PfGAP45) phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

The cellular geography of aurora kinases

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.183

An essential Aurora-related kinase transiently associates with spindle pole bodies during Plasmodium falciparum erythrocytic schizogony

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.183

Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Drugging the Plasmodium kinome: the benefits of academia-industry synergy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Calcium-dependent signaling and kinases in apicomplexan parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Dissection of mechanisms involved in the regulation of Plasmodium falciparum calcium-dependent protein kinase 4

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Plasmodium berghei calcium-dependent protein kinase 3 is required for ookinete gliding motility and mosquito midgut invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Identification, cloning, and mutational analysis of the casein kinase 1 cDNA of the malaria parasite, Plasmodium falciparum. Stage-specific expression of the gene

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Protein kinases as drug targets in parasitic protozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Identification and initial characterization of three novel cyclin-related proteins of the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Activation of a Plasmodium falciparum cdc2-related kinase by heterologous p25 and cyclin H. Functional characterization of a P. falciparum cyclin homologue

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.183

The malarial CDK Pfmrk and its effector PfMAT1 phosphorylate DNA replication proteins and co-localize in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Functional characterization of both MAP kinases of the human malaria parasite Plasmodium falciparum by reverse genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Disruption of Plasmodium berghei merozoite surface protein 7 gene modulates parasite growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Pfnek-1, a NIMA-related kinase from the human malaria parasite Plasmodium falciparum Biochemical properties and possible involvement in MAPK regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Pfnek3: an atypical activator of a MAP kinase in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

PfSRPK1, a Novel Splicing-related Kinase from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Structural and evolutionary divergence of eukaryotic protein kinases in Apicomplexa

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Two nucleus-localized CDK-like kinases with crucial roles for malaria parasite erythrocytic replication are involved in phosphorylation of splicing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Mitotic regulation by NIMA-related kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Plasmodium falciparum NIMA-related kinase Pfnek-1: sex specificity and assessment of essentiality for the erythrocytic asexual cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Proteome analysis of separated male and female gametocytes reveals novel sex-specific Plasmodium biology

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

An essential role for the Plasmodium Nek-2 Nima-related protein kinase in the sexual development of malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

SAM domain-dependent activity of PfTKL3, an essential tyrosine kinase-like kinase of the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

PfPK7, an atypical MEK-related protein kinase, reflects the absence of classical three-component MAPK pathways in the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Characterization of a UBC13 kinase in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

A novel protein kinase family in Plasmodium falciparum is differentially transcribed and secreted to various cellular compartments of the host cell

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Plasmodium falciparum FIKK kinase members target distinct components of the erythrocyte membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

High efficiency transfection of Plasmodium berghei facilitates novel selection procedures

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Orthologous gene sequences of merozoite surface protein 1 (MSP1) from Plasmodium reichenowi and P. gallinaceum confirm an ancient divergence of P. falciparum alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

An evolutionary perspective on the kinome of malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites' boundaries.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

The Plasmodium falciparum schizont phosphoproteome reveals extensive phosphatidylinositol and cAMP-protein kinase A signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Insights into the Plasmodium falciparum schizont phospho-proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Principles of CDK regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Protein kinase inhibitors: contributions from structure to clinical compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2: increasing hit rate via virtual screening methods.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Chemical genetics of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Lead optimization of antimalarial propafenone analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

An all-purpose antimalarial drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Global phenotypic screening for antimalarials

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Heterologous expression of plasmodial proteins for structural studies and functional annotation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Targeting protein kinases in the malaria parasite: update of an antimalarial drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

The H89 cAMP-dependent protein kinase inhibitor blocks Plasmodium falciparum development in infected erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Identification and characterization of novel small molecules as potent inhibitors of the plasmodial calcium-dependent protein kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Rational inhibitor design and iterative screening in the identification of selective plasmodial cyclin dependent kinase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Characteristics of the Plasmodium falciparum PK5 ATP-binding site: implications for the design of novel antimalarial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Alisiaquinones and alisiaquinol, dual inhibitors of Plasmodium falciparum enzyme targets from a New Caledonian deep water sponge

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Antiplasmodial activities of homogentisic acid derivative protein kinase inhibitors isolated from a Vanuatu marine sponge Pseudoceratina sp

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Structures of P. falciparum PfPK5 test the CDK regulation paradigm and suggest mechanisms of small molecule inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Structures of parasitic CDPK domains point to a common mechanism of activation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Advancing cancer drug discovery towards more agile development of targeted combination therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

Toxoplasma gondii cyclic GMP-dependent kinase: chemotherapeutic targeting of an essential parasite protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

The Serine/Threonine/Tyrosine Phosphoproteome of the Model BacteriumBacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

A novel cyclic GMP-dependent protein kinase is expressed in the ring stage of the Plasmodium falciparum life cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.183

21 January 2018

Identifiers

DOI

10.4155/FMC.12.183

1 reference

28 August 2017

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