Implications of pharmacogenetics for individualizing drug treatment and for study design (Q35102211)

6 August 2017

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title

Implications of pharmacogenetics for individualizing drug treatment and for study design (English)

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Przemysław M. Mrozikiewicz

6 August 2017

author

object named as

Przemyslaw M Mrozikiewicz

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6 August 2017

Christian Meisel

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6 August 2017

Thomas Gerloff

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6 August 2017

Julia Kirchheiner

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6 August 2017

Przemyslaw Niewinski

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6 August 2017

Jürgen Brockmöller

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6 August 2017

Ivar Roots

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6 August 2017

publication date

15 March 2003

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Journal of Molecular Medicine

6 August 2017

published in

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

154-167

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Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies

6 August 2017

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Impact of CYP2C9 amino acid polymorphisms on glyburide kinetics and on the insulin and glucose response in healthy volunteers

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Impact of CYP2C9 and CYP2C19 polymorphisms on tolbutamide kinetics and the insulin and glucose response in healthy volunteers

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Effects of CYP2C19 and CYP2C9 genetic polymorphisms on the disposition of and blood glucose lowering response to tolbutamide in humans

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Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine [seecomments]

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The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

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Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

21 January 2018

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Relevance of p-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation

21 January 2018

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Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness

21 January 2018

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The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma

21 January 2018

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The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization

21 January 2018

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Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease

21 January 2018

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

21 January 2018

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A common polymorphism associated with antibiotic-induced cardiac arrhythmia

21 January 2018

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PlA2 polymorphism and efficacy of aspirin

21 January 2018

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Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension

21 January 2018

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The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An Approach Using Designed Tienilic Acid Derivatives and Molecular Modeling

21 January 2018

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Reduced inhibition by abciximab in platelets with the PlA2 polymorphism

21 January 2018

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12 December 2020

Predicting the cytochrome P450 mediated metabolism of xenobiotics.

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Putative active site template model for cytochrome P4502C9 (tolbutamide hydroxylase)

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12 December 2020

Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment

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12 December 2020

Tacrolimus oral bioavailability doubles with coadministration of ketoconazole*

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12 December 2020

ACE (I/D) genotype as a predictor of the magnitude and duration of the response to an ACE inhibitor drug (enalaprilat) in humans

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12 December 2020

Effect of CYP2C polymorphisms on the pharmacokinetics of phenytoin in Japanese patients with epilepsy

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12 December 2020

Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9

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12 December 2020

The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism

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12 December 2020

Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences

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12 December 2020

Allelic and functional variability of cytochrome P4502C9.

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The Role of a Common Variant of the Cholesteryl Ester Transfer Protein Gene in the Progression of Coronary Atherosclerosis

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12 December 2020

Influence of functional MDR1 gene polymorphisms on P-glycoprotein activity in CD34+ hematopoietic stem cells.

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12 December 2020

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Genetic association between sensitivity to warfarin and expression of CYP2C9*3

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12 December 2020

Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy.

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12 December 2020

Enzymatic deficiency in primaquine-sensitive erythrocytes

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12 December 2020

Pharmacogenetic interactions between beta-blocker therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure

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12 December 2020

Pharmacogenetics of tolbutamide metabolism in humans

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12 December 2020

Correctness of prediction of the CYP2D6 phenotype confirmed by genotyping 47 intermediate and poor metabolizers of debrisoquine.

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12 December 2020

The effect of genetic polymorphisms in CYP2C9 on sulphamethoxazole N-hydroxylation.

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12 December 2020

Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene

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Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus

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CYP2C9 Ile359 and Leu359 variants: enzyme kinetic study with seven substrates

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12 December 2020

Disposition kinetics and metabolism of omeprazole in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation recruited from an Oriental population.

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Pharmacogenetic applications of the Human Genome project

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Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: a new type of drug/drug interaction

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12 December 2020

Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications

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The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

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12 December 2020

A comparison of molecular and enzyme-based assays for the detection of thiopurine methyltransferase mutations

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12 December 2020

Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans

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12 December 2020

PROLONGED HYPOGLYCEMIA SECONDARY TO TOLBUTAMIDE

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12 December 2020

Platelet GP IIIa Pl(A) polymorphisms display different sensitivities to agonists

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12 December 2020

The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells

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12 December 2020

P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs

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12 December 2020

Hepatic metabolism of tolbutamide: characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition

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12 December 2020

MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects

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12 December 2020

10.1007/S00109-002-0417-4

Identifiers

DOI

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6 August 2017

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