mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice. (Q34429001)

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English	mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.	scientific article

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17 January 2020

mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice (English)

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17 January 2020

photoreceptor protein

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17 January 2020

Michael P. Snyder

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Michael Snyder

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17 January 2020

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Chen Zhao

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Douglas Yasumura

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Michael Matthes

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Marcia Lloyd

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17 January 2020

Gregory Nielsen

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Kelly Ahern

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Dean Bok

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Joshua L Dunaief

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Matthew M LaVail

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17 January 2020

Douglas Vollrath

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6 December 2010

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17 January 2020

Journal of Clinical Investigation

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17 January 2020

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17 January 2020

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17 January 2020

369-383

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17 January 2020

Generation of Cre transgenic mice with postnatal RPE-specific ocular expression

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Focus on molecules: MERTK.

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Abundant lipid and protein components of drusen

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Taz-tead1 links cell-cell contact to zeb1 expression, proliferation, and dedifferentiation in retinal pigment epithelial cells

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Pro-angiogenic effect of IFNgamma is dependent on the PI3K/mTOR/translational pathway in human retinal pigmented epithelial cells

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Missense mutations in a retinal pigment epithelium protein, bestrophin-1, cause retinitis pigmentosa

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Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger

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Mertk drives myosin II redistribution during retinal pigment epithelial phagocytosis

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Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

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Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007156

27 October 2018

Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007156

27 October 2018

The Rpe65 Leu450Met variation increases retinal resistance against light-induced degeneration by slowing rhodopsin regeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007156

27 October 2018

Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007156

27 October 2018

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007156

27 October 2018

Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007156

27 October 2018

Macular pattern dystrophy associated with a mutation of mitochondrial DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007156

27 October 2018

TAM receptor function in the retinal pigment epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007156

27 October 2018

Glucose uptake, hexose monophosphate shunt activity, and oxygen consumption in cultured human retinal pigment epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21135502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THE METABOLISM OF RETINAL PIGMENT CELL EPITHELIUM. II. RESPIRATION AND GLYCOLYSIS

1 reference

https://pubmed.ncbi.nlm.nih.gov/21135502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related macular degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/21135502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related Macular Degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/21135502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human retinal pigment epithelium cell changes and expression of alphaB-crystallin: a biomarker for retinal pigment epithelium cell change in age-related macular degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/21135502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related macular degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/21135502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI44303

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21135502%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21135502%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21135502%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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