Romidepsin (FK228) and its analogs directly inhibit phosphatidylinositol 3-kinase activity and potently induce apoptosis as histone deacetylase/phosphatidylinositol 3-kinase dual inhibitors (Q34394171)

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Language	Label	Description	Also known as
English	Romidepsin (FK228) and its analogs directly inhibit phosphatidylinositol 3-kinase activity and potently induce apoptosis as histone deacetylase/phosphatidylinositol 3-kinase dual inhibitors	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Romidepsin (FK228) and its analogs directly inhibit phosphatidylinositol 3-kinase activity and potently induce apoptosis as histone deacetylase/phosphatidylinositol 3-kinase dual inhibitors (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

author name string

Ken Saijo

1

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Tadashi Katoh

2

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Hideki Shimodaira

3

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Akifumi Oda

4

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Ohgi Takahashi

5

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Chikashi Ishioka

6

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

publication date

12 October 2012

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Europe PubMed Central

PubMed publication ID

1 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

103

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Europe PubMed Central

PubMed publication ID

1 August 2017

11

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Europe PubMed Central

PubMed publication ID

1 August 2017

1994-2001

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

The phosphoinositide 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

Functional analysis of PIK3CA gene mutations in human colorectal cancer

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

Tenets of PTEN tumor suppression

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

Advances in development of phosphatidylinositol 3-kinase inhibitors

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

Yeast as a screening tool.

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

Assessment of PTEN tumor suppressor activity in nonmammalian models: the year of the yeast.

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

Romidepsin: a novel histone deacetylase inhibitor for cancer

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

Histone deacetylase inhibitors: molecular mechanisms of action

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

An inactivating mutation in HDAC2 leads to dysregulation of apoptosis mediated by APAF1.

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor.

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

Depsipeptide induces cell death in Hodgkin lymphoma-derived cell lines

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

Inhibition of PI3K by ZSTK474 suppressed tumor growth not via apoptosis but G0/G1 arrest

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

RNA interference-mediated depletion of phosphoinositide 3-kinase activates forkhead box class O transcription factors and induces cell cycle arrest and apoptosis in breast carcinoma cells.

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma.

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

Total synthesis of the bicyclic depsipeptide HDAC inhibitors spiruchostatins A and B, 5''-epi-spiruchostatin B, FK228 (FR901228) and preliminary evaluation of their biological activity

1 reference

https://api.crossref.org/works/10.1111%2FCAS.12002

21 January 2018

FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22924958

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of phosphatidylinositol 3-kinase/Akt signaling pathway is a determinant of the sensitivity to a novel histone deacetylase inhibitor, FK228, in lung adenocarcinoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22924958

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pleitropic drug ABC transporters from Saccharomyces cerevisiae.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22924958

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/22924958

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22924958

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/CAS.12002

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

ResearchGate publication ID

0 references

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