Brown fat as a therapy for obesity and diabetes (Q34099153)

31 July 2017

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title

Brown fat as a therapy for obesity and diabetes (English)

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31 July 2017

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C Ronald Kahn

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31 July 2017

Aaron M Cypess

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31 July 2017

language of work or name

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1 April 2010

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Current Opinion in Endocrinology, Diabetes and Obesity

31 July 2017

published in

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

143-149

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Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism

31 July 2017

cites work

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5 July 2018

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Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex

5 July 2018

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C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists

5 July 2018

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Effect of the dual peroxisome proliferator-activated receptor-alpha/gamma agonist aleglitazar on risk of cardiovascular disease in patients with type 2 diabetes (SYNCHRONY): a phase II, randomised, dose-ranging study

5 July 2018

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TGR5: an emerging bile acid G-protein-coupled receptor target for the potential treatment of metabolic disorders

5 July 2018

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The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue.

5 July 2018

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High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity

5 July 2018

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Brown adipose tissue--when it pays to be inefficient

5 July 2018

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Functional brown adipose tissue in healthy adults

5 July 2018

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Identification and importance of brown adipose tissue in adult humans

5 July 2018

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Cold-activated brown adipose tissue in healthy men

5 July 2018

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A mathematical model of murine metabolic regulation by leptin: energy balance and defense of a stable body weight

5 July 2018

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Deficiency of growth differentiation factor 3 protects against diet-induced obesity by selectively acting on white adipose.

5 July 2018

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New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

5 July 2018

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PRDM16 controls a brown fat/skeletal muscle switch

5 July 2018

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The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from beta3-adrenoceptor agonists

5 July 2018

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Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

5 July 2018

1 reference

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The efficiency of cellular energy transduction and its implications for obesity

5 July 2018

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RNAi screens reveal novel metabolic regulators: RIP140, MAP4k4 and the lipid droplet associated fat specific protein (FSP) 27.

5 July 2018

1 reference

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Developmental origin of fat: tracking obesity to its source.

5 July 2018

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Transcriptional control of brown fat determination by PRDM16

5 July 2018

1 reference

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Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states

5 July 2018

1 reference

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Unexpected evidence for active brown adipose tissue in adult humans

5 July 2018

1 reference

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Sirtuin functions in health and disease

5 July 2018

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Thermogenic and metabolic antiobesity drugs: rationale and opportunities

5 July 2018

1 reference

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Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Adipocytes as regulators of energy balance and glucose homeostasis

5 July 2018

1 reference

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Improvement of glycemic control, triglycerides, and HDL cholesterol levels with muraglitazar, a dual (alpha/gamma) peroxisome proliferator-activated receptor activator, in patients with type 2 diabetes inadequately controlled with metformin monother

5 July 2018

2 references

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5 July 2018

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Bone morphogenetic proteins and growth differentiation factors as drug targets in cardiovascular and metabolic disease

28 October 2018

1 reference

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Central nervous system biogenic amine targets for control of appetite and energy expenditure

5 July 2018

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5 July 2018

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5 July 2018

1 reference

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FGF-21 as a novel metabolic regulator

5 July 2018

1 reference

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Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin

5 July 2018

1 reference

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Pharmacological therapies for obesity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

IKK-beta links inflammation to obesity-induced insulin resistance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Bone morphogenetic protein 7: a novel treatment for chronic renal and bone disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Nuclear receptor corepressor RIP140 regulates fat accumulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

PET/CT in oncology: integration into clinical management of lymphoma, melanoma, and gastrointestinal malignancies.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Brown adipose tissue: function and physiological significance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Uptake in supraclavicular area fat ("USA-Fat"): description on 18F-FDG PET/CT.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Effect of a 28-d treatment with L-796568, a novel beta(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

The morphologic spectrum of hibernoma: a clinicopathologic study of 170 cases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Disruption of klotho gene causes an abnormal energy homeostasis in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Molecular regulation of adipocyte differentiation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Luxuskonsumption, Diet-Induced Thermogenesis and Brown Fat: The Case in Favour

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

The distribution of brown adipose tissue in the human

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Thermogenesis in human brown adipose tissue and skeletal muscle induced by sympathomimetic stimulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Tissue distribution of cold-induced thermogenesis in conscious warm- or cold-acclimated rats reevaluated from changes in tissue blood flow: The dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Effect of nicotine and ephedrine on the accumulation of 18F-FDG in brown adipose tissue.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Acute effect of L-796568, a novel beta 3-adrenergic receptor agonist, on energy expenditure in obese men.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593105

Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold

28 October 2018

1 reference

12 December 2020

Association of Pheochromocytomas with Brown Fat Tumors

1 reference

12 December 2020

The occurrence of brown adipose tissue in outdoor workers

1 reference

12 December 2020

The characterization and energetic potential of brown adipose tissue in man

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12 December 2020

Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a beta3-adrenoceptor agonist

1 reference

12 December 2020

Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans

1 reference

12 December 2020

Anti-obesity therapies

1 reference

12 December 2020

10.1097/MED.0B013E328337A81F

Identifiers

DOI

1 reference

release_4rjxkss7ezalzc35h5v7zsqanq

31 July 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/4rjxkss7ezalzc35h5v7zsqanq

24 November 2022

mapped directly with Wikidata item

PMC publication ID

3593105

1 reference

31 July 2017

1 reference