TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damage (Q33899861)

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Language	Label	Description	Also known as
English	TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damage	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damage (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

0 references

author name string

Abhinav K Jain

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Kendra Allton

2

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Aundrietta D Duncan

3

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Michelle C Barton

4

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

publication date

1 July 2014

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Europe PubMed Central

PubMed publication ID

29 July 2017

Molecular and Cellular Biology

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Europe PubMed Central

PubMed publication ID

29 July 2017

34

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Europe PubMed Central

PubMed publication ID

29 July 2017

14

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

2695-2709

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells

1 reference

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The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity

1 reference

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p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells

1 reference

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TRIM24 links a non-canonical histone signature to breast cancer

1 reference

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Making sense of ubiquitin ligases that regulate p53

1 reference

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5 July 2018

Regulation of p53: TRIM24 enters the RING.

1 reference

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5 July 2018

Trim24 targets endogenous p53 for degradation

1 reference

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5 July 2018

Modes of p53 regulation

1 reference

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Blinded by the Light: The Growing Complexity of p53

1 reference

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Modifications of p53: competing for the lysines

1 reference

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A complex barcode underlies the heterogeneous response of p53 to stress

1 reference

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p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo

1 reference

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Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha

1 reference

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Signaling by estrogens

1 reference

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

1 reference

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p53 in health and disease

1 reference

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5 July 2018

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

1 reference

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5 July 2018

Genetic and expression aberrations of E3 ubiquitin ligases in human breast cancer

1 reference

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5 July 2018

ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage

1 reference

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The complexity of p53 stabilization and activation

1 reference

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p53 ubiquitination: Mdm2 and beyond

1 reference

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5 July 2018

TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases

1 reference

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MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation

1 reference

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ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

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The p53 pathway: positive and negative feedback loops

1 reference

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Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

1 reference

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Post-translational modification of p53 in tumorigenesis

1 reference

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Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species

1 reference

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The ubiquitin ligase COP1 is a critical negative regulator of p53

1 reference

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Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

1 reference

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

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A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter

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Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

1 reference

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ATM and related protein kinases: safeguarding genome integrity

1 reference

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 reference

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

1 reference

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The tripartite motif family identifies cell compartments

1 reference

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1 reference

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Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

1 reference

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

1 reference

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1 reference

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Regulation of p53 stability by Mdm2

1 reference

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Mdm2 promotes the rapid degradation of p53

1 reference

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Expression of the mutated p53 tumor suppressor protein and its molecular and biochemical characterization in multidrug resistant MCF-7/Adr human breast cancer cells

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A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors

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Estrogen receptors: bioactivities and interactions with cell signaling pathways

1 reference

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mdm2 expression is induced by wild type p53 activity

1 reference

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The p53-mdm-2 autoregulatory feedback loop

1 reference

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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Participation of p53 protein in the cellular response to DNA damage

1 reference

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Levels of p53 protein increase with maturation in human hematopoietic cells

1 reference

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Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

1 reference

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29 October 2018

Identifiers

10.1128/MCB.01705-12

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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