The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors (Q33613105)

28 July 2017

title

The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors (English)

1 reference

28 July 2017

Michael Hedvat

1 reference

28 July 2017

Dennis Huszar

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28 July 2017

Andreas Herrmann

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28 July 2017

Joseph M Gozgit

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28 July 2017

Anne Schroeder

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28 July 2017

Adam Sheehy

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28 July 2017

Ralf Buettner

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28 July 2017

David Proia

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28 July 2017

Claudia M Kowolik

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28 July 2017

Hong Xin

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28 July 2017

Brian Armstrong

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28 July 2017

Geraldine Bebernitz

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28 July 2017

Shaobu Weng

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28 July 2017

Lin Wang

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28 July 2017

Minwei Ye

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28 July 2017

Kristen McEachern

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28 July 2017

Huawei Chen

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28 July 2017

Deborah Morosini

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28 July 2017

Kirsten Bell

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28 July 2017

Marat Alimzhanov

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28 July 2017

Stephanos Ioannidis

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28 July 2017

Patricia McCoon

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28 July 2017

Zhu A Cao

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28 July 2017

Hua Yu

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28 July 2017

Richard Jove

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28 July 2017

Michael Zinda

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28 July 2017

language of work or name

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1 December 2009

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28 July 2017

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28 July 2017

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28 July 2017

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28 July 2017

page(s)

487-497

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IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

28 July 2017

cites work

1 reference

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Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2.

14 July 2018

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Box 2 region of the oncostatin M receptor determines specificity for recruitment of Janus kinases and STAT5 activation

14 July 2018

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Autocrine IL-6 signaling: a key event in tumorigenesis?

14 July 2018

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Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphoma

14 July 2018

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Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

14 July 2018

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A role for JAK2 mutations in myeloproliferative diseases

14 July 2018

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Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression

14 July 2018

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14 July 2018

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STAT-mediated EGFR signaling in cancer.

14 July 2018

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Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer.

14 July 2018

1 reference

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Regulation of ovarian carcinoma SKOV-3 cell proliferation and secretion of MMPs by autocrine IL-6.

14 July 2018

1 reference

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Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment.

14 July 2018

1 reference

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STAT3: a multifaceted oncogene

14 July 2018

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The role of IL-6 and STAT3 in inflammation and cancer

14 July 2018

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Interleukin-6 regulation of prostate cancer cell growth

14 July 2018

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Inhibition of HER-kinase activation prevents ERK-mediated degradation of PPARgamma

14 July 2018

1 reference

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The STATs of cancer--new molecular targets come of age

14 July 2018

1 reference

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Real time analysis of STAT3 nucleocytoplasmic shuttling

14 July 2018

1 reference

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Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck

14 July 2018

1 reference

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Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

14 July 2018

1 reference

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Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812011

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812011

Activation of Stat3 preassembled with platelet-derived growth factor beta receptors requires Src kinase activity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812011

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812011

Transforming properties of chimeric TEL-JAK proteins in Ba/F3 cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812011

Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway .

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812011

14 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812011

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

14 July 2018

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Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

14 July 2018

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STATs and gene regulation

14 July 2018

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Regulation of STAT-dependent pathways by growth factors and cytokines.

14 July 2018

1 reference

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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

14 July 2018

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Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.

14 July 2018

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Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

14 July 2018

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Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

14 July 2018

1 reference

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A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

14 July 2018

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Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

14 July 2018

1 reference

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The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812011

Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812011

STAT3 is enriched in nuclear bodies

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812011

Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812011

Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812011

Stat3 activation in prostatic carcinomas.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812011

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812011

Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19962667

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Myeloproliferative disorders

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19962667

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCR.2009.10.015

1 reference

28 July 2017

1 reference

28 July 2017

1 reference