Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. (Q33209208)

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English	Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.	scientific article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558054%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558054%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

3

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5 January 2020

6

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5 January 2020

Galina Selivanova

8

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5 January 2020

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Natalia Issaeva

1

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5 January 2020

Przemyslaw Bozko

2

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5 January 2020

Marina Protopopova

4

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5 January 2020

Lisette G G C Verhoef

5

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5 January 2020

Aladdin Pramanik

7

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5 January 2020

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21 November 2004

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5 January 2020

Nature Medicine

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5 January 2020

10

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5 January 2020

12

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5 January 2020

1321-1328

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5 January 2020

Surfing the p53 network

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21 January 2018

The IARC TP53 database: new online mutation analysis and recommendations to users

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21 January 2018

Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

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21 January 2018

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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21 January 2018

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

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21 January 2018

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

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21 January 2018

Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors

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21 January 2018

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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21 January 2018

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

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21 January 2018

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

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21 January 2018

Specific binding of proinsulin C-peptide to human cell membranes

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21 January 2018

p53 Latency. C-terminal domain prevents binding of p53 core to target but not to nonspecific DNA sequences.

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21 January 2018

Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter

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21 January 2018

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

1 reference

https://api.crossref.org/works/10.1038%2FNM1146

21 January 2018

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

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21 January 2018

Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells

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21 January 2018

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

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21 January 2018

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

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https://api.crossref.org/works/10.1038%2FNM1146

21 January 2018

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

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https://api.crossref.org/works/10.1038%2FNM1146

21 January 2018

p53 has a direct apoptogenic role at the mitochondria

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21 January 2018

Parc: a cytoplasmic anchor for p53.

1 reference

https://api.crossref.org/works/10.1038%2FNM1146

21 January 2018

Slow tight binding inhibition of proteinase K by a proteinaceous inhibitor: conformational alterations responsible for conferring irreversibility to the enzyme-inhibitor complex.

1 reference

https://api.crossref.org/works/10.1038%2FNM1146

21 January 2018

Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21.

1 reference

https://api.crossref.org/works/10.1038%2FNM1146

21 January 2018

p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels

1 reference

https://api.crossref.org/works/10.1038%2FNM1146

21 January 2018

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

1 reference

https://api.crossref.org/works/10.1038%2FNM1146

21 January 2018

Biological significance of a small highly conserved region in the N terminus of the p53 tumour suppressor protein.

1 reference

https://api.crossref.org/works/10.1038%2FNM1146

21 January 2018

Regulation of mutant p53 temperature-sensitive DNA binding.

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21 January 2018

Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins. CRC Cell Transformation Group

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21 January 2018

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

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https://api.crossref.org/works/10.1038%2FNM1146

21 January 2018

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

1 reference

https://api.crossref.org/works/10.1038%2FNM1146

21 January 2018

Solution structure of the tetrameric minimum transforming domain of p53

1 reference

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21 January 2018

Suppression of human colorectal carcinoma cell growth by wild-type p53

1 reference

https://api.crossref.org/works/10.1038%2FNM1146

21 January 2018

Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism

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21 January 2018

The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region.

1 reference

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21 January 2018

Control of cell growth by c-Myc in the absence of cell division

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21 January 2018

Transient excess of MYC activity can elicit genomic instability and tumorigenesis

1 reference

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21 January 2018

CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

1 reference

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21 January 2018

Signaling to p53: breaking the MDM2-p53 circuit

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7 January 2021

based on heuristic

inferred from DOI database lookup

A matter of life and cell death

1 reference

https://api.crossref.org/works/10.1038%2FNM1146

7 January 2021

based on heuristic

inferred from DOI database lookup

A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines

1 reference

https://api.crossref.org/works/10.1038%2FNM1146

7 January 2021

based on heuristic

inferred from DOI database lookup

The initial evaluation of non-peptidic small-molecule HDM2 inhibitors based on p53-HDM2 complex structure

1 reference

https://api.crossref.org/works/10.1038%2FNM1146

7 January 2021

based on heuristic

inferred from DOI database lookup

Mdm2 binding to a conformationally sensitive domain on p53 can be modulated by RNA

1 reference

https://api.crossref.org/works/10.1038%2FNM1146

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FNM1146

7 January 2021

based on heuristic

inferred from DOI database lookup

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