Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice (Q30531298)

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English	Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

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9

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M G Caron

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14 August 2017

author name string

J P R Jacobsen

1

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14 August 2017

W B Siesser

2

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14 August 2017

B D Sachs

3

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Europe PubMed Central

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14 August 2017

S Peterson

4

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Europe PubMed Central

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14 August 2017

M J Cools

5

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14 August 2017

V Setola

6

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Europe PubMed Central

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14 August 2017

J H A Folgering

7

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14 August 2017

G Flik

8

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14 August 2017

language of work or name

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publication date

3 May 2011

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14 August 2017

Molecular Psychiatry

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14 August 2017

17

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14 August 2017

7

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Europe PubMed Central

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14 August 2017

694-704

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Europe PubMed Central

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14 August 2017

Effects of the 5-HT(4) receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels

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Acute and repeated flibanserin administration in female rats modulates monoamines differentially across brain areas: a microdialysis study

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5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants

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Structural brain abnormalities in major depressive disorder: a selective review of recent MRI studies

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Pharmacological manipulation of kynurenic acid: potential in the treatment of psychiatric disorders

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Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter.

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Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants

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Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals.

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Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency

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Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo

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5-HT receptor regulation of neurotransmitter release

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Important messages in the 'post': recent discoveries in 5-HT neurone feedback control

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Serotonin-1A receptor imaging in recurrent depression: replication and literature review

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20 June 2018

Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder

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20 June 2018

No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects

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Potential mechanisms of action of atypical antipsychotic medications in treatment-resistant depression and anxiety.

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Serotonin and depression: a disconnect between the advertisements and the scientific literature

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20 June 2018

Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD.

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20 June 2018

Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression

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From galactorrhea to osteopenia: rethinking serotonin-prolactin interactions.

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Monoamine oxidase and head-twitch response in mice. Mechanisms of alpha-methylated substrate derivatives

1 reference

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20 June 2018

Stress-induced hyperthermia and anxiety: pharmacological validation

1 reference

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20 June 2018

Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior.

1 reference

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20 June 2018

Do animal models of anxiety predict anxiolytic-like effects of antidepressants?

1 reference

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20 June 2018

Crosstalk between the norepinephrine and serotonin systems and its role in the antidepressant response

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20 June 2018

Regulation of 5-HT(1A) receptor-stimulated [35S]-GtpgammaS binding as measured by quantitative autoradiography following chronic agonist administration

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20 June 2018

Psychopharmacology of 5-HT(1A) receptors.

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20 June 2018

PET imaging of serotonin 1A receptor binding in depression

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Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level

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7 January 2021

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Differential effects of serotonin (5-HT) lesions and synthesis blockade on neuropeptide-Y immunoreactivity and 5-HT1A, 5-HT1B/1D and 5-HT2A/2C receptor binding sites in the rat cerebral cortex.

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20 June 2018

Extracellular dopamine, norepinephrine, and serotonin in the ventral tegmental area and nucleus accumbens of freely moving rats during intracerebral dialysis following systemic administration of cocaine and other uptake blockers

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20 June 2018

WAY100635-induced augmentation of the 5-HT-elevating action of citalopram: relative importance of the dose of the 5-HT1A (auto)receptor blocker versus that of the 5-HT reuptake inhibitor

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20 June 2018

The 5-HT1A antagonist WAY-100635 selectively potentiates the presynaptic effects of serotonergic antidepressants in rat brain

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20 June 2018

Attempted suicide characteristics and cerebrospinal fluid amine metabolites in depressed inpatients

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20 June 2018

Rapid agonist-induced internalization of the 5-hydroxytryptamine2A receptor occurs via the endosome pathway in vitro

1 reference

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Blunted serotonergic responsivity in depressed inpatients

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Aggression, suicide, and serotonin: relationships to CSF amine metabolites

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20 June 2018

5-Hydroxytryptamine in the Hind-Brain of Depressive Suicides

1 reference

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20 June 2018

The biochemistry of affective disorders

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20 June 2018

Serotonergic dysfunction in depression

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20 June 2018

Effect of the 5-HT1A receptor agonist 8-OH-DPAT on the release of 5-HT in dorsal and median raphe-innervated rat brain regions as measured by in vivo microdialysis

1 reference

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20 June 2018

5-HT1A receptor responsivity in anxiety disorders and depression

1 reference

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20 June 2018

Tryptophan depletion during continuous CSF sampling in healthy human subjects

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21 January 2018

Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims

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21 January 2018

Effects of imipramine on extracellular serotonin and noradrenaline concentrations in ACTH-treated rats

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21 January 2018

Effect of chronic tryptophan depletion on the circadian rhythm of wheel-running activity in rats

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Serotonin-1A receptor function in the dorsal raphe nucleus following chronic administration of the selective serotonin reuptake inhibitor sertraline

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Insensitivity of NMRI mice to selective serotonin reuptake inhibitors in the tail suspension test can be reversed by co-treatment with 5-hydroxytryptophan

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21 January 2018

Relationship between brain serotonin transporter binding, plasma concentration and behavioural effect of selective serotonin reuptake inhibitors

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Neurochemical responses to antidepressants in the prefrontal cortex of mice and their efficacy in preclinical models of anxiety-like and depression-like behavior: a comparative and correlational study

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21 January 2018

Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations

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https://api.crossref.org/works/10.1038%2FMP.2011.50

21 January 2018

Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response

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21 January 2018

Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population

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21 January 2018

Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment

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21 January 2018

Changes of body temperature and extracellular serotonin level in the preoptic area and anterior hypothalamus after thermal or serotonergic pharmacological stimulation of freely moving rats

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21 January 2018

Acute treatment with the antidepressant fluoxetine internalizes 5-HT1A autoreceptors and reduces the in vivo binding of the PET radioligand [18F]MPPF in the nucleus raphe dorsalis of rat.

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https://api.crossref.org/works/10.1038%2FMP.2011.50

21 January 2018

Pharmacology of Antidepressants

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21 January 2018

Increased 5-HT(2A) receptor binding in euthymic, medication-free patients recovered from depression: a positron emission study with [(11)C]MDL 100,907.

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Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice.

1 reference

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26 November 2018

Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536482

26 November 2018

Changes in extracellular serotonin in rat hypothalamus affect thermoregulatory function.

1 reference

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26 November 2018

AAPS-FDA Workshop White Paper: microdialysis principles, application, and regulatory perspectives

1 reference

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Prolactin response to D-fenfluramine and suicidal behavior in depressed patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/21537332

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Blunted temperature and cortisol responses to ipsapirone in major depression: lack of enhancement by electroconvulsive therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21537332

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A physiological method to selectively decrease brain serotonin release

1 reference

https://pubmed.ncbi.nlm.nih.gov/21537332

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Neurobiology of suicidal behaviour

1 reference

https://pubmed.ncbi.nlm.nih.gov/21537332

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based on heuristic

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Increased serotonin-2 binding sites in frontal cortex of suicide victims

1 reference

https://pubmed.ncbi.nlm.nih.gov/21537332

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Complete amino acid sequence of mouse prolactin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21537332

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Effects of local application of 5-HT and 8-OH-DPAT into the dorsal and median raphe nuclei on core temperature in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/21537332

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5-HT1A receptor sensitivity in major depression. A neuroendocrine study with buspirone

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4-(2'-Methoxy-phenyl)-1-[2'-(n-2"-pyridinyl)-p-iodobenzamido]-ethyl- piperazine ([125I]p-MPPI) as a new selective radioligand of serotonin-1A sites in rat brain: in vitro binding and autoradiographic studies

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https://pubmed.ncbi.nlm.nih.gov/21537332

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Neurotransmitters and suicidal behavior. The evidence from cerebrospinal fluid studies

1 reference

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Acute tryptophan depletion attenuates the prolactin response to d-fenfluramine challenge in healthy human subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/21537332

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5-HT1A Receptor Function in Normal Subjects on Clinical Doses of Fluoxetine Blunted Temperature and Hormone Responses to Ipsapirone Challenge

1 reference

https://pubmed.ncbi.nlm.nih.gov/21537332

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Identifiers

10.1038/MP.2011.50

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

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