Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome (Q30574939)

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Language	Label	Description	Also known as
English	Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome (English)

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

pharmacokinetics

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based on heuristic

inferred from title

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object named as

Ingrid A Holm

10

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Walter E Kaufmann

22

object named as

Walter E Kaufmann

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Europe PubMed Central

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21 August 2017

author name string

Omar S Khwaja

1

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21 August 2017

Eugenia Ho

2

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21 August 2017

Katherine V Barnes

3

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21 August 2017

Heather M O'Leary

4

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21 August 2017

Luis M Pereira

5

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21 August 2017

Yaron Finkelstein

6

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21 August 2017

Charles A Nelson

7

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21 August 2017

Vanessa Vogel-Farley

8

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21 August 2017

Geneva DeGregorio

9

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21 August 2017

Umakanth Khatwa

11

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21 August 2017

Kush Kapur

12

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21 August 2017

Mark E Alexander

13

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21 August 2017

Deirdre M Finnegan

14

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21 August 2017

Nicole G Cantwell

15

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21 August 2017

Alexandra C Walco

16

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Europe PubMed Central

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21 August 2017

Leonard Rappaport

17

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21 August 2017

Matt Gregas

18

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Europe PubMed Central

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21 August 2017

Raina N Fichorova

19

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21 August 2017

Michael W Shannon

20

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21 August 2017

Mriganka Sur

21

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21 August 2017

language of work or name

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publication date

12 March 2014

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21 August 2017

Proceedings of the National Academy of Sciences of the United States of America

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21 August 2017

111

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21 August 2017

12

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21 August 2017

4596-4601

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970488

20 June 2018

Insulin-like growth factor-1 and its derivatives: potential pharmaceutical application for treating neurological conditions

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20 June 2018

Insulinotropic treatments exacerbate metabolic syndrome in mice lacking MeCP2 function

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Changing the perspective on early development of Rett syndrome

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Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen.

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20 June 2018

IGF1 as a Potential Treatment for Rett Syndrome: Safety Assessment in Six Rett Patients

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20 June 2018

Neurodevelopmental effects of insulin-like growth factor signaling

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20 June 2018

The insulin-like growth factors and growth disorders of childhood

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Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome

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20 June 2018

The short-time structural plasticity of dendritic spines is altered in a model of Rett syndrome

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20 June 2018

Translational research: Rett syndrome and tuberous sclerosis complex

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Peptide mimetics of neurotrophins and their receptors

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20 June 2018

Clinical assessment of DSM-IV anxiety disorders in fragile X syndrome: prevalence and characterization

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20 June 2018

Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: a systematic review of observational studies

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20 June 2018

Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056.

1 reference

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20 June 2018

Rett syndrome: revised diagnostic criteria and nomenclature

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20 June 2018

Rett syndrome diagnostic criteria: lessons from the Natural History Study

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20 June 2018

A wearable sensor for unobtrusive, long-term assessment of electrodermal activity

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20 June 2018

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

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20 June 2018

Mecasermin (recombinant human insulin-like growth factor I).

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20 June 2018

Correction of fragile X syndrome in mice.

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20 June 2018

Reversal of neurological defects in a mouse model of Rett syndrome

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20 June 2018

Depression, anxiety, and resting frontal EEG asymmetry: a meta-analytic review

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20 June 2018

Breathing generation and potential pharmacotherapeutic approaches to central respiratory disorders

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20 June 2018

MeCP2 expression and function during brain development: implications for Rett syndrome's pathogenesis and clinical evolution

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20 June 2018

Reliability and validity of an assessment instrument for anxiety, depression, and mood among individuals with mental retardation

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20 June 2018

Clinical trials and treatment prospects

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20 June 2018

Clinical manifestations and stages of Rett syndrome

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20 June 2018

Validation of a new respiratory inductive plethysmograph

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20 June 2018

Early childhood predictors of adult anxiety disorders

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20 June 2018

Recent insights into hyperventilation from the study of Rett syndrome.

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20 June 2018

Methyl CpG-binding protein 2 (a mutation of which causes Rett syndrome) directly regulates insulin-like growth factor binding protein 3 in mouse and human brains

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21 January 2018

Dexmedetomidine pharmacodynamics: part I: crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers

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21 January 2018

The Rett Syndrome Behaviour Questionnaire (RSBQ): refining the behavioural phenotype of Rett syndrome

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21 January 2018

Social impairments in Rett syndrome: characteristics and relationship with clinical severity

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Insulin-like growth factor 1 (IGF1) and its active peptide (1-3)IGF1 enhance the expression of synaptic markers in neuronal circuits through different cellular mechanisms

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21 January 2018

Pubertal trajectory in females with Rett syndrome: a population-based study

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Effects of fluoxetine treatment on striatal dopamine transporter binding and cerebrospinal fluid insulin-like growth factor-1 in children with autism

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21 January 2018

Insulin-like growth factor-1 is associated with cognitive outcome in infantile spasms

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Disturbances in cardiorespiratory function during day and night in Rett syndrome

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The development of visual- and auditory processing in Rett syndrome: an ERP study

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Report of the committee on methods of clinical examination in electroencephalography

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EEG asymmetry, power, and temperament in children

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A comparison of the electroencephalogram between institutionalized and community children in Romania.

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Report of the first case of precocious puberty in Rett syndrome

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26 November 2018

Pharmacokinetics of recombinant human insulin-like growth factor I given subcutaneously to healthy volunteers and to patients with growth hormone receptor deficiency

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Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: a randomized, controlled, phase 2 trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/24623853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.1311141111

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

2014PNAS..111.4596K

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

ResearchGate publication ID

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