transmembrane protein 173 (Q21112990)

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mammalian protein found in Homo sapiens
  • Mediator of IRF3 activation
  • endoplasmic reticulum interferon stimulator
  • N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
  • ERIS
  • stimulator of interferon protein
  • hMITA
  • mitochondrial mediator of IRF3 activation
  • endoplasmic reticulum IFN stimulator
  • stimulator of interferon genes protein
  • TMEM173
  • STING1 protein, human
edit
Language Label Description Also known as
English
transmembrane protein 173
mammalian protein found in Homo sapiens
  • Mediator of IRF3 activation
  • endoplasmic reticulum interferon stimulator
  • N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
  • ERIS
  • stimulator of interferon protein
  • hMITA
  • mitochondrial mediator of IRF3 activation
  • endoplasmic reticulum IFN stimulator
  • stimulator of interferon genes protein
  • TMEM173
  • STING1 protein, human

Statements

molecular function
protein binding
determination method or standard
IPI
17 references
retrieved
1 January 2018
stated in
ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response
GOA
curator
UniProt
UniProt protein ID
Q86WV6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
GOA
curator
UniProt
UniProt protein ID
Q86WV6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING
GOA
curator
UniProt
UniProt protein ID
Q86WV6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible gene I-like receptor-mediated immune signaling in a ubiquitination-dependent manner
GOA
curator
UniProt
UniProt protein ID
Q86WV6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
Activation of STAT6 by STING is critical for antiviral innate immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
IFI16 is an innate immune sensor for intracellular DNA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-induced Innate Immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
identical protein binding
determination method or standard
IPI
5 references
retrieved
1 January 2018
stated in
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
retrieved
1 January 2018
stated in
The structural basis for the sensing and binding of cyclic di-GMP by STING
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IPI
cell component
endoplasmic reticulum membrane
determination method or standard
IBA
IDA
IEA
TAS
6 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q86WV6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IEA
retrieved
1 January 2018
stated in
RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms
GOA
curator
UniProt
UniProt protein ID
Q86WV6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IDA
retrieved
1 January 2018
stated in
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
GOA
curator
UniProt
UniProt protein ID
Q86WV6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IBA
biological process
innate immune response
determination method or standard
IBA
IDA
IEA
IMP
6 references
retrieved
1 January 2018
stated in
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
GOA
curator
UniProt
UniProt protein ID
Q86WV6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IMP
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q86WV6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IEA
retrieved
1 January 2018
stated in
RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms
GOA
curator
UniProt
UniProt protein ID
Q86WV6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IDA
retrieved
1 January 2018
stated in
The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA
GOA
curator
UniProt
UniProt protein ID
Q86WV6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV6
determination method or standard
IBA

Identifiers

MeSH descriptor ID
C532857
subject named as
STING1 protein, human
0 references
PDB structure ID
 
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