CD40 ligand (Q2071144)

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mammalian protein found in Homo sapiens

TNF-related activation protein
CD40 antigen ligand
CD40LG
Tumor necrosis factor ligand superfamily member 5
tumor necrosis factor (ligand) superfamily member 5
T-cell antigen Gp39
CD40-L
TRAP
T-B cell-activating molecule

Language	Label	Description	Also known as
English	CD40 ligand	mammalian protein found in Homo sapiens	TNF-related activation protein CD40 antigen ligand CD40LG Tumor necrosis factor ligand superfamily member 5 tumor necrosis factor (ligand) superfamily member 5 T-cell antigen Gp39 CD40-L TRAP T-B cell-activating molecule

Statements

1 reference

20 December 2017

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

1 reference

InterPro Release 66.0

http://www.ebi.ac.uk/interpro/protein/P29965

Tumour necrosis factor-like domain superfamily

1 reference

InterPro Release 66.0

http://www.ebi.ac.uk/interpro/protein/P29965

1 reference

20 December 2017

UniProt protein ID

1 reference

20 December 2017

UniProt protein ID

molecular function

cytokine activity

determination method or standard

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

CD40 receptor binding

determination method or standard

1 reference

24 April 2018

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

tumor necrosis factor receptor binding

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

protein binding

determination method or standard

1 reference

24 April 2018

The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

24 April 2018

Human CD40‐ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

extracellular region

determination method or standard

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

external side of plasma membrane

determination method or standard

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

intracellular anatomical structure

determination method or standard

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

extracellular space

determination method or standard

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

biological process

leukocyte cell-cell adhesion

determination method or standard

1 reference

24 April 2018

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

positive regulation of interleukin-12 production

determination method or standard

1 reference

24 April 2018

Interleukin-12 production by human alveolar macrophages is controlled by the autocrine production of interleukin-10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

regulation of immunoglobulin production

determination method or standard

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

protein secretion

determination method or standard

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

negative regulation of apoptotic process

determination method or standard

1 reference

24 April 2018

CD40 Ligand Blocks Apoptosis Induced by Tumor Necrosis Factor α, Glucocorticoids, and Etoposide in Osteoblasts and the Osteocyte-Like Cell Line Murine Long Bone Osteocyte-Y4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

tumor necrosis factor-mediated signaling pathway

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

platelet activation

determination method or standard

1 reference

24 April 2018

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

positive regulation of endothelial cell apoptotic process

determination method or standard

1 reference

24 April 2018

A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

B cell proliferation

determination method or standard

1 reference

24 April 2018

Cleavage of membrane-bound CD40 ligand is not required for inducing B cell proliferation and differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

immune response

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

regulation of immune response

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

B cell differentiation

determination method or standard

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

inflammatory response

determination method or standard

1 reference

24 April 2018

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

T cell costimulation

determination method or standard

1 reference

24 April 2018

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

positive regulation of NF-kappaB transcription factor activity

determination method or standard

1 reference

24 April 2018

The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

positive regulation of JUN kinase activity

determination method or standard

1 reference

24 April 2018

The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

positive regulation of interleukin-4 production

determination method or standard

1 reference

24 April 2018

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

positive regulation of interleukin-10 production

determination method or standard

1 reference

24 April 2018

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

positive regulation of T cell proliferation

determination method or standard

1 reference

24 April 2018

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

regulation of signaling receptor activity

determination method or standard

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29965&geneProductId=UniProtKB:P29965

determination method or standard

Gene Atlas image

PBB GE CD40LG 207892 at fs.png
732 × 530; 12 KB

0 references

Tumour necrosis factor, conserved site

1 reference

InterPro Release 66.0

http://www.ebi.ac.uk/interpro/protein/P29965

Tumour necrosis factor domain

1 reference

InterPro Release 66.0

http://www.ebi.ac.uk/interpro/protein/P29965

Identifiers

RefSeq protein ID

1 reference

18 May 2018

UniProt protein ID

1 reference

20 December 2017

UniProt protein ID

Ensembl protein ID

ENSP00000359663

1 reference

Ensembl Release 91

Ensembl protein ID

ENSP00000359663

ENSP00000359662

1 reference

Ensembl Release 91

Ensembl protein ID

ENSP00000359662

1 reference

Freebase Data Dumps

publication date

28 October 2013

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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