Cyclin-dependent kinase inhibitor 2A (Q14907028)

InterPro Release 68.0

http://www.ebi.ac.uk/interpro/protein/P51480

1 reference

28 February 2018

1 reference

28 February 2018

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

protein binding

4 references

24 April 2018

Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

protein kinase binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

p53 binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

cyclin-dependent protein serine/threonine kinase inhibitor activity

Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

Cloning and characterization of murine p16INK4a and p15INK4b genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

transcription factor binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

SUMO transferase activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

ubiquitin-protein transferase inhibitor activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

disordered domain specific binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

ubiquitin ligase inhibitor activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

cell component

cytoplasm

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

senescence-associated heterochromatin focus

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

granular component

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

nucleoplasm

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

nucleolus

9 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

Nucleophosmin is required for DNA integrity and p19Arf protein stability

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

Defining the molecular basis of Arf and Hdm2 interactions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

mitochondrion

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

nuclear body

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

biological process

replicative senescence

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

negative regulation of cell-matrix adhesion

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

positive regulation of cellular senescence

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

1 reference

24 April 2018

negative regulation of cell population proliferation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

heterochromatin assembly

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

positive regulation of macrophage apoptotic process

1 reference

24 April 2018

p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

negative regulation of phosphorylation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

positive regulation of smooth muscle cell apoptotic process

1 reference

24 April 2018

p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

negative regulation of transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

negative regulation of NF-kappaB transcription factor activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

protein polyubiquitination

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

autophagy of mitochondrion

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

negative regulation of protein kinase activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

activation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

regulation of cell cycle

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

Cloning and characterization of murine p16INK4a and p15INK4b genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

apoptotic mitochondrial changes

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

regulation of G2/M transition of mitotic cell cycle

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

protein sumoylation

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

negative regulation of B cell proliferation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

regulation of protein stability

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

protein destabilization

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

negative regulation of immature T cell proliferation in thymus

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

positive regulation of protein sumoylation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

positive regulation of apoptotic process

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

positive regulation of DNA damage response, signal transduction by p53 class mediator

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

negative regulation of cyclin-dependent protein serine/threonine kinase activity

Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

positive regulation of transcription by RNA polymerase II

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

regulation of protein export from nucleus

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

somatic stem cell division

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

protein stabilization

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

positive regulation of DNA-binding transcription factor activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

negative regulation of ubiquitin-protein transferase activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

mitochondrial depolarization

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

positive regulation of apoptotic process involved in mammary gland involution

p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development

2 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

protein K63-linked ubiquitination

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

regulation of cell cycle

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

cellular senescence

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

positive regulation of protein localization to nucleus

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

positive regulation of signal transduction by p53 class mediator

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

regulation of apoptotic DNA fragmentation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

negative regulation of proteolysis involved in cellular protein catabolic process

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

regulation of protein targeting to mitochondrion

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

negative regulation of ubiquitin-dependent protein catabolic process

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

24 April 2018

Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

positive regulation of gene expression

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

negative regulation of ubiquitin protein ligase activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

amyloid fibril formation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

negative regulation of protein neddylation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

G1/S transition of mitotic cell cycle

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

response to organonitrogen compound

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

response to organic cyclic compound

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

response to drug

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

negative regulation of hepatocyte proliferation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480

ankyrin repeat-containing domain

has part(s)

1 reference

InterPro Release 68.0

http://www.ebi.ac.uk/interpro/protein/P51480

ankyrin repeat

1 reference

InterPro Release 68.0

http://www.ebi.ac.uk/interpro/protein/P51480

Identifiers

1 reference

16 March 2018

1 reference

16 March 2018

1 reference

28 February 2018

1 reference

1 reference

1 reference

imported from Wikimedia project

UniProt

16 November 2015