Immunoadsorption enables successful rAAV5-mediated repeated hepatic gene delivery in nonhuman primates (Q90000829)

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scientific article published on 01 September 2019

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English	Immunoadsorption enables successful rAAV5-mediated repeated hepatic gene delivery in nonhuman primates	scientific article published on 01 September 2019

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31501158%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Immunoadsorption enables successful rAAV5-mediated repeated hepatic gene delivery in nonhuman primates (English)

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10 April 2020

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primates

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5

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10 April 2020

Gloria González Aseguinolaza

7

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10 April 2020

author name string

David Salas

1

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10 April 2020

Karin L Kwikkers

2

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10 April 2020

Nerea Zabaleta

3

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10 April 2020

Andrea Bazo

4

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10 April 2020

Sander J van Deventer

6

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10 April 2020

Valerie Ferreira

8

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10 April 2020

publication date

1 September 2019

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10 April 2020

3

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10 April 2020

17

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10 April 2020

2632-2641

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10 April 2020

Neutralization of vesicular stomatitis virus (VSV) by human complement requires a natural IgM antibody present in human serum

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elimination kinetics of plasma exchange

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid elimination of a high-titer spontaneous factor V antibody by extracorporeal antibody-based immunoadsorption and immunosuppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Removal of baboon and human antiporcine IgG and IgM natural antibodies by immunoadsorption. Results of in vitro and in vivo studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative evaluation of liver-specific promoters from retroviral vectors after in vivo transduction of hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elimination of acquired factor VIII antibodies by extracorporal antibody-based immunoadsorption (Ig-Therasorb)

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and safety of immunoglobulin apheresis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasmapheresis and immunoadsorption: different techniques and their current role in medical therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene therapy vectors based on adeno-associated virus type 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of antibody and complement removal with a Ig-Therasorb column in a xenogeneic working heart model

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of plasmapheresis in the management of acute hepatic failure in children

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complement-mediated enhancement of antibody function for neutralization of pseudotype virus containing hepatitis C virus E2 chimeric glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sustained high-level expression of human factor IX (hFIX) after liver-targeted delivery of recombinant adeno-associated virus encoding the hFIX gene in rhesus macaques

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insect cells as a factory to produce adeno-associated virus type 2 vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors for liver gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human immunoglobulin inhibits liver transduction by AAV vectors at low AAV2 neutralizing titers in SCID mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human leukocyte antigen polymorphisms: variable humoral immune responses to viral vaccines

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term expression and repeated administration of AAV type 1, 2 and 5 vectors in skeletal muscle of immunocompetent adult mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence of serum IgG and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: implications for gene therapy using AAV vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma exchange and immunoadsorption for autoimmune neurologic diseases - current guidelines and future perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preexisting immunity and low expression in primates highlight translational challenges for liver-directed AAV8-mediated gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term safety and efficacy following systemic administration of a self-complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 capsid proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of pre-existing immunity on gene transfer to nonhuman primate liver with adeno-associated virus 8 vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A 10 Patient Case Report on the Impact of Plasmapheresis Upon Neutralizing Factors Against Adeno-associated Virus (AAV) Types 1, 2, 6, and 8

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenovirus-associated virus vector-mediated gene transfer in hemophilia B

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-mediated rejection: pathogenesis, prevention, treatment, and outcomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: an open-label trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma Exchange and Immunoadsorption of Patients with Thoracic Organ Transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minimizing the inhibitory effect of neutralizing antibody for efficient gene expression in the liver with adeno-associated virus 8 vectors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoadsorption for connective tissue disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The selective therapeutic apheresis procedures

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overcoming preexisting humoral immunity to AAV using capsid decoys

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasmapheresis eliminates the negative impact of AAV antibodies on microdystrophin gene expression following vascular delivery.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AB0 incompatible kidney transplantation using unspecific immunoadsorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of natural IgM concentration on gene therapy with adenovirus type 5 vectors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoadsorption with regenerating systems in neurological disorders --A single center experience

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of adeno-associated virus neutralizing antibody activity for clinical application

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adeno-associated virus serotypes for gene therapeutics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of Readministration of a Recombinant Adeno-Associated Virus Vector Expressing Acid Alpha-Glucosidase in Pompe Disease: Preclinical to Clinical Planning

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variability in Humoral Immunity to Measles Vaccine: New Developments

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single point mutation in adeno-associated viral vectors -DJ capsid leads to improvement for gene delivery in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I open label liver-directed gene therapy clinical trial for acute intermittent porphyria

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improvement of Adeno-Associated Virus-Mediated Liver Transduction Efficacy by Regional Administration in Macaca fascicularis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Successful Repeated Hepatic Gene Delivery in Mice and Non-human Primates Achieved by Sequential Administration of AAV5ch and AAV1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoadsorption in Autoimmune Diseases Affecting the Kidney.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strategy to detect pre-existing immunity to AAV gene therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene therapy with adeno-associated virus vector 5-human factor IX in adults with hemophilia B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autologous and Heterologous Cell Therapy for Hemophilia B toward Functional Restoration of Factor IX.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of neutralizing antibodies against AAV is a key consideration in gene transfer to nonhuman primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AAV Immunogenicity: A Matter of Sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic hFIX Activity Achieved after Single AAV5-hFIX Treatment in Hemophilia B Patients and NHPs with Pre-existing Anti-AAV5 NABs

1 reference

https://pubmed.ncbi.nlm.nih.gov/31501158

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOODADVANCES.2019000380

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31501158%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31501158%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31501158%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

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