New insights from the widening homogeneity perspective to target intratumor heterogeneity (Q88682253)

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scientific article published on 04 May 2018

Language	Label	Description	Also known as
English	New insights from the widening homogeneity perspective to target intratumor heterogeneity	scientific article published on 04 May 2018

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scholarly article

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26 March 2020

4 references

23 July 2020

14 November 2020

25 January 2021

8 February 2021

New insights from the widening homogeneity perspective to target intratumor heterogeneity (English)

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26 March 2020

genetic predisposition to disease

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23 July 2020

10 September 2020

precision medicine

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14 November 2020

genetic heterogeneity

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25 January 2021

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8 February 2021

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based on heuristic

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author name string

Mengying Tong

1

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26 March 2020

Ziqian Deng

2

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26 March 2020

Xiaolong Zhang

3

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26 March 2020

Bin He

4

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26 March 2020

Mengying Yang

5

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26 March 2020

Wei Cheng

6

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26 March 2020

Quentin Liu

7

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26 March 2020

publication date

4 May 2018

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26 March 2020

23 July 2020

14 November 2020

25 January 2021

8 February 2021

Cancer communications

5 references

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26 March 2020

23 July 2020

14 November 2020

25 January 2021

8 February 2021

38

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26 March 2020

1

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26 March 2020

17

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26 March 2020

copyright license

Creative Commons Attribution 4.0 International

5 references

Europe PubMed Central

23 July 2020

Europe PubMed Central

10 September 2020

Europe PubMed Central

14 November 2020

Europe PubMed Central

25 January 2021

Europe PubMed Central

8 February 2021

The clonal evolution of tumor cell populations

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential of continuous tumour cell lines for establishing patterns of cross-resistance and collateral sensitivity in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro cross-resistance and collateral sensitivity in seven resistant small-cell lung cancer cell lines: preclinical identification of suitable drug partners to taxotere, taxol, topotecan and gemcitabin

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chromatin signatures of pluripotent cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The epithelial-mesenchymal transition generates cells with properties of stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

1 reference

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12 December 2020

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Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

1 reference

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12 December 2020

based on heuristic

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In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.

1 reference

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12 December 2020

based on heuristic

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Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

1 reference

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12 December 2020

based on heuristic

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An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation

1 reference

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12 December 2020

based on heuristic

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Notch Signaling Pathway as a Therapeutic Target in Breast Cancer

1 reference

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12 December 2020

based on heuristic

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Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells

1 reference

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12 December 2020

based on heuristic

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The Wnt/β-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer

1 reference

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12 December 2020

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A decade of exploring the cancer epigenome - biological and translational implications

1 reference

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12 December 2020

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Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

1 reference

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12 December 2020

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The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A DNA hypermethylation module for the stem/progenitor cell signature of cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

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Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

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The future of epigenetic therapy in solid tumours--lessons from the past.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

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Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

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Integrated genomic characterization of endometrial carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

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Comprehensive molecular characterization of clear cell renal cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

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Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

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What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

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Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

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Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

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Comprehensive molecular characterization of urothelial bladder carcinoma

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12 December 2020

based on heuristic

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Cancer Systems Biology: a peek into the future of patient care?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evolution of the cancer stem cell model

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor genetic analyses of patients with metastatic renal cell carcinoma and extended benefit from mTOR inhibitor therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRAF inhibitors induce metastasis in RAS mutant or inhibitor-resistant melanoma cells by reactivating MEK and ERK signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tracking genomic cancer evolution for precision medicine: the lung TRACERx study

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advancing clinical oncology through genome biology and technology.

1 reference

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12 December 2020

based on heuristic

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Cancer systems biology: embracing complexity to develop better anticancer therapeutic strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The promise of circulating tumor cell analysis in cancer management

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genotyping cell-free tumor DNA in the blood to detect residual disease and drug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

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Combined vemurafenib and cobimetinib in BRAF-mutated melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological and therapeutic impact of intratumor heterogeneity in cancer evolution

1 reference

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12 December 2020

based on heuristic

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Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution

1 reference

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12 December 2020

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Targeting the adaptability of heterogeneous aneuploids

1 reference

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Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

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Clinical management of breast cancer heterogeneity

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Feasibility of Large-Scale Genomic Testing to Facilitate Enrollment Onto Genomically Matched Clinical Trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Molecular Taxonomy of Primary Prostate Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of ubiquitous and heterogeneous mutations in cell-free DNA from patients with early-stage non-small-cell lung cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cellular origins of drug resistance in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-free circulating tumor DNA in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic alterations and molecular subtypes of gastric cancers in Asians

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-cell Sequencing Reveals Variants in ARID1A, GPRC5A and MLL2 Driving Self-renewal of Human Bladder Cancer Stem Cells.

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

A landscape of pharmacogenomic interactions in cancer.

1 reference

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12 December 2020

based on heuristic

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Limits to Personalized Cancer Medicine.

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-cell exome sequencing identifies mutations in KCP, LOC440040, and LOC440563 as drivers in renal cell carcinoma stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spatial heterogeneity in medulloblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tracking the Evolution of Non-Small-Cell Lung Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comprehensive Genomic Characterization of Upper Tract Urothelial Carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intertumoral Heterogeneity within Medulloblastoma Subgroups

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor Evolution as a Therapeutic Target

1 reference

https://pubmed.ncbi.nlm.nih.gov/29764517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S40880-018-0287-Y

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Europe PubMed Central

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26 March 2020

PMC publication ID

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26 March 2020

PubMed publication ID

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26 March 2020

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