Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis (Q64387024)

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scientific article published on 01 April 2019

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English	Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis	scientific article published on 01 April 2019

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scholarly article

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25 April 2020

Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis (English)

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25 April 2020

amyotrophic lateral sclerosis

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Erika N Guerrero

1

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25 April 2020

Joy Mitra

2

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25 April 2020

Haibo Wang

3

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25 April 2020

Suganya Rangaswamy

4

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25 April 2020

Pavana M Hegde

5

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25 April 2020

Priyadarshini Basu

6

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25 April 2020

K S Rao

7

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25 April 2020

Muralidhar L Hegde

8

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25 April 2020

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publication date

1 April 2019

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25 April 2020

Human Molecular Genetics

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25 April 2020

28

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25 April 2020

5

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25 April 2020

2459-2476

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25 April 2020

Crystal structure of an Xrcc4-DNA ligase IV complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The comet assay for DNA damage and repair: principles, applications, and limitations

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TDP-43 in differential diagnosis of motor neuron disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TDP-43 A315T mutation in familial motor neuron disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage-induced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of oxidative damage by gene-specific quantitative PCR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TDP-43 regulates its mRNA levels through a negative feedback loop

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative DNA damage in neurons: implication of ku in neuronal homeostasis and survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NEIL2 protects against oxidative DNA damage induced by sidestream smoke in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA Ligase IV regulates XRCC4 nuclear localization

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress in neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TDP-43/FUS in motor neuron disease: Complexity and challenges.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Curcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retracted: TDP-43 causes neurotoxicity and cytoskeletal dysfunction in primary cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An Inducible Alpha-Synuclein Expressing Neuronal Cell Line Model for Parkinson's Disease1

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

1 reference

https://pubmed.ncbi.nlm.nih.gov/31067307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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