mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. (Q44905183)

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English	mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. (English)

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

apoptotic process

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author name string

Pradip K Majumder

1

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Europe PubMed Central

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7 December 2017

Phillip G Febbo

2

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Europe PubMed Central

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7 December 2017

Rachel Bikoff

3

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Europe PubMed Central

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7 December 2017

Raanan Berger

4

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Europe PubMed Central

PubMed publication ID

7 December 2017

Qi Xue

5

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Europe PubMed Central

PubMed publication ID

7 December 2017

Louis M McMahon

6

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Europe PubMed Central

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7 December 2017

Judith Manola

7

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Europe PubMed Central

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7 December 2017

James Brugarolas

8

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Europe PubMed Central

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7 December 2017

Timothy J McDonnell

9

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7 December 2017

Todd R Golub

10

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7 December 2017

Massimo Loda

11

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7 December 2017

Heidi A Lane

12

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7 December 2017

William R Sellers

13

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7 December 2017

publication date

23 May 2004

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7 December 2017

Nature Medicine

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7 December 2017

10

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7 December 2017

6

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7 December 2017

594-601

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7 December 2017

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Direct control of the Forkhead transcription factor AFX by protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Early clinical experience with a novel rapamycin derivative

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI.

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

The impact of bcl-2 expression and bax deficiency on prostate homeostasis in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Signal transduction to hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

PIK3CA is implicated as an oncogene in ovarian cancer.

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Bcl-2 proto-oncogene expression in low- and high-grade prostatic intraepithelial neoplasia

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Mammalian target of rapamycin: a new molecular target for breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Targeting HIF-1 for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

21 January 2018

Identifiers

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

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