Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing i (Q43000076)

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scientific article published in September 2001

Language	Label	Description	Also known as
English	Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing i	scientific article published in September 2001

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing i (English)

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

1 reference

based on heuristic

inferred from title

author name string

Sandy JD

1

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Verscharen C

2

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

language of work or name

0 references

publication date

1 September 2001

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Biochemical Journal

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

358

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Pt 3

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

615-626

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

26 May 2018

ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

26 May 2018

Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

26 May 2018

Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.

1 reference

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26 May 2018

The use of cleavage site specific antibodies to delineate protein processing and breakdown pathways

1 reference

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26 May 2018

Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

26 May 2018

Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine

1 reference

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Characterization of aggrecan retained and lost from the extracellular matrix of articular cartilage. Involvement of carboxyl-terminal processing in the catabolism of aggrecan

1 reference

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26 May 2018

Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints

1 reference

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Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent

1 reference

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26 May 2018

Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage

1 reference

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Characterization of proteoglycans isolated from associative extracts of human articular cartilage

1 reference

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Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain

1 reference

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26 May 2018

A longitudinal study of cartilage matrix metabolism in patients with cruciate ligament rupture--synovial fluid concentrations of aggrecan fragments, stromelysin-1 and tissue inhibitor of metalloproteinase-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

26 May 2018

Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

26 May 2018

Proteoglycans isolated from dissociative extracts of differently aged human articular cartilage: characterization of naturally occurring hyaluronan-binding fragments of aggrecan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

26 May 2018

The properties of proteoglycan prepared from human articular cartilage by using associative caesium chloride gradients of high and low starting densities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

26 May 2018

Separation and characterization of two populations of aggregating proteoglycans from cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

26 May 2018

The identification and characterization of two populations of aggregating proteoglycans of high buoyant density isolated from post-natal human articular cartilages of different ages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

26 May 2018

Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue

1 reference

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26 May 2018

Isolation of the N-terminal globular protein domains from cartilage proteoglycans. Identification of G2 domain and its lack of interaction with hyaluronate and link protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

26 May 2018

Age-related changes in protein-related epitopes of human articular-cartilage proteoglycans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

26 May 2018

Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

26 May 2018

The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

26 May 2018

Age-related changes in the composition and structure of human articular-cartilage proteoglycans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

26 May 2018

The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

16 August 2018

Cathepsin B: an alternative protease for the generation of an aggrecan 'metalloproteinase' cleavage neoepitope

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

16 August 2018

Immunolocalization of the cleavage of the aggrecan core protein at the Asn341-Phe342 bond, as an indicator of the location of the metalloproteinases active in the lysis of the rat growth plate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

16 August 2018

Aggrecan degradation in human intervertebral disc and articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222096

16 August 2018

Glycosaminoglycan sulfation in human osteoarthritis. Disease-related alterations at the non-reducing termini of chondroitin and dermatan sulfate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11535123

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inferred from PubMed ID database lookup

Changes in sulfation patterns of chondroitin sulfate in equine articular cartilage and synovial fluid in response to aging and osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11535123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of caesium sulphate density gradient centrifugation to analyse proteoglycans from human articular cartilages of different ages

1 reference

https://pubmed.ncbi.nlm.nih.gov/11535123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in levels of serum keratan sulfate following cartilage proteoglycan degradation in the rabbit knee joint

1 reference

https://pubmed.ncbi.nlm.nih.gov/11535123

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inferred from PubMed ID database lookup

Studies on the hyaluronate binding properties of newly synthesized proteoglycans purified from articular chondrocyte cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/11535123

12 December 2020

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inferred from PubMed ID database lookup

Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11535123

12 December 2020

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Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at this site in vivo in human articular cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/11535123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11535123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related changes in cartilage proteoglycans: quantitative electron microscopic studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/11535123

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based on heuristic

inferred from PubMed ID database lookup

Changes in cartilage composition and physical properties due to stromelysin degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11535123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathways of aggrecan processing in joint tissues. Implications for disease mechanism and monitoring

1 reference

https://pubmed.ncbi.nlm.nih.gov/11535123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MMP-8 (neutrophil collagenase) mRNA and aggrecanase cleavage products are present in normal and osteoarthritic human articular cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/11535123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of cartilage aggrecan by collagenase-3 (MMP-13)

1 reference

https://pubmed.ncbi.nlm.nih.gov/11535123

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inferred from PubMed ID database lookup

Aggrecan turnover in human articular cartilage: use of aspartic acid racemization as a marker of molecular age

1 reference

https://pubmed.ncbi.nlm.nih.gov/11535123

12 December 2020

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Identifiers

10.1042/0264-6021:3580615

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

ResearchGate publication ID

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