Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale. (Q42408230)

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scientific article published on October 2010

Language	Label	Description	Also known as
English	Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale.	scientific article published on October 2010

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20497038%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale (English)

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Europe PubMed Central

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3 February 2020

6

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3 February 2020

7

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3 February 2020

author name string

Martin Lock

1

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3 February 2020

Mauricio Alvira

2

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3 February 2020

Luk H Vandenberghe

3

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3 February 2020

Arabinda Samanta

4

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3 February 2020

Jaan Toelen

5

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3 February 2020

publication date

1 October 2010

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3 February 2020

Human Gene Therapy

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3 February 2020

21

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3 February 2020

10

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3 February 2020

1259-1271

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3 February 2020

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2957274/fullTextXML

based on heuristic

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Efficient serotype-dependent release of functional vector into the culture medium during adeno-associated virus manufacturing.

1 reference

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28 May 2018

Adenovirus-adeno-associated virus hybrid for large-scale recombinant adeno-associated virus production

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Producing recombinant adeno-associated virus in foster cells: overcoming production limitations using a baculovirus-insect cell expression strategy

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Large-scale adeno-associated viral vector production using a herpesvirus-based system enables manufacturing for clinical studies

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Scalable purification of adeno-associated virus serotype 1 (AAV1) and AAV8 vectors, using dual ion-exchange adsorptive membranes.

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A simplified baculovirus-AAV expression vector system coupled with one-step affinity purification yields high-titer rAAV stocks from insect cells

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Transient transfection methods for clinical adeno-associated viral vector production

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Safety and efficacy of gene transfer for Leber's congenital amaurosis

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Clinical gene therapy using recombinant adeno-associated virus vectors

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High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells

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Scalable serum-free production of recombinant adeno-associated virus type 2 by transfection of 293 suspension cells

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28 May 2018

Production and characterization of adeno-associated viral vectors

1 reference

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Transfection of mammalian cells using linear polyethylenimine is a simple and effective means of producing recombinant adeno-associated virus vectors

1 reference

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Treatment of human disease by adeno-associated viral gene transfer

1 reference

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Quantification of adeno-associated virus particles and empty capsids by optical density measurement

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Production of clinical-grade recombinant adeno-associated virus vectors

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A versatile and scalable two-step ion-exchange chromatography process for the purification of recombinant adeno-associated virus serotypes-2 and -5.

1 reference

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28 May 2018

Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors

1 reference

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28 May 2018

Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

1 reference

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28 May 2018

Streamlined large-scale production of recombinant adeno-associated virus (rAAV) vectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2957274

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Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column.

1 reference

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28 May 2018

Adeno-associated virus vectors can be efficiently produced without helper virus

1 reference

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Factors influencing recombinant adeno-associated virus production

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Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus

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Identification of factors that contribute to recombinant AAV2 particle aggregation and methods to prevent its occurrence during vector purification and formulation

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Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: a multicenter, double-blind, placebo-controlled trial

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Scalable purification of adeno-associated virus type 2, 4, or 5 using ion-exchange chromatography

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Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

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Novel tools for production and purification of recombinant adenoassociated virus vectors

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Spectrophotometric determination of iodixanol in subcellular fractions of mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20497038

12 December 2020

based on heuristic

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Identifiers

10.1089/HUM.2010.055

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Europe PubMed Central

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3 February 2020

PMC publication ID

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Europe PubMed Central

PMC publication ID

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3 February 2020

PubMed publication ID

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Europe PubMed Central

PMC publication ID

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3 February 2020

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