Production of clinical-grade recombinant adeno-associated virus vectors (Q35012878)

5 August 2017

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title

Production of clinical-grade recombinant adeno-associated virus vectors (English)

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5 August 2017

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Richard O Snyder

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5 August 2017

Terence R Flotte

series ordinal

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5 August 2017

publication date

1 October 2002

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Current Opinion in Biotechnology

5 August 2017

published in

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5 August 2017

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5 August 2017

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5 August 2017

page(s)

418-423

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Epidemiology of adenovirus-associated virus infection in a nursery population

5 August 2017

cites work

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

The AAV origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Site-specific integration by adeno-associated virus

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

The adeno-associated virus (AAV) Rep protein acts as both a repressor and an activator to regulate AAV transcription during a productive infection

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

The cellular transcription factor SP1 and an unknown cellular protein are required to mediate Rep protein activation of the adeno-associated virus p19 promoter.

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

New developments in the generation of Ad-free, high-titer rAAV gene therapy vectors

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Titration of AAV-2 particles via a novel capsid ELISA: packaging of genomes can limit production of recombinant AAV-2.

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

High-titer adeno-associated viral vectors from a Rep/Cap cell line and hybrid shuttle virus

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Production of recombinant adeno-associated virus vectors using a packaging cell line and a hybrid recombinant adenovirus

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Recombinant adeno-associated viral vector production using stable packaging and producer cell lines

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Recombinant adeno-associated virus type 2 replication and packaging is entirely supported by a herpes simplex virus type 1 amplicon expressing Rep and Cap

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and Cap.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Highly purified recombinant adeno-associated virus vectors are biologically active and free of detectable helper and wild-type viruses

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Purification of recombinant adeno-associated virus vectors by column chromatography and its performance in vivo

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column.

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Reporter expression persists 1 year after adeno-associated virus-mediated gene transfer to the optic nerve

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson’s disease in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Practical aspects of the development of ex vivo and in vivo gene therapy for Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Adeno-associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Effect of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Nonrandom transduction of recombinant adeno-associated virus vectors in mouse hepatocytes in vivo: cell cycling does not influence hepatocyte transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

A phase I study of an adeno-associated virus-CFTR gene vector in adult CF patients with mild lung disease

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Efficient and persistent gene transfer of AAV-CFTR in maxillary sinus

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

A phase I/II study of tgAAV-CF for the treatment of chronic sinusitis in patients with cystic fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

A phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector.

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Targeted integration of adeno-associated virus (AAV) into human chromosome 19

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Adeno-associated virus 2-mediated gene transfer in vivo: organ-tropism and expression of transduced sequences in mice

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

The kinetics of rAAV integration in the liver

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https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Development of animal models for adeno-associated virus site-specific integration

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

Adeno-associated virus site-specifically integrates into a muscle-specific DNA region

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2802%2900369-5

7 January 2021

10.1016/S0958-1669(02)00369-5

Identifiers

DOI

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5 August 2017

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