News & Comment

Here, we introduce Artificial Intelligence Ready and Equitable Atlas for Diabetes Insights (AI-READI), a multidisciplinary data-generation project designed to create and share a multimodal dataset optimized for artificial intelligence research in type 2 diabetes mellitus.

We have lost a distinguished scientist who made indelible contributions to our knowledge of exercise physiology and diabetes and was an advocate for mentoring and transparency in research.

Although Western societies are mesmerized by the power of new anti-obesity drugs, we must not forget how diet can affect metabolic outcomes. In this Focus issue, and accompanying web collection, we showcase a series of Reviews, Comments and original research articles that present up-to-date evidence on how dietary interventions can affect cardiometabolic health.

Extracellular vesicles (EVs) are now recognized as powerful modulators of metabolism, and thus the new field of EV-mediated metabolic regulation is growing exponentially. Here, we discuss special experimental considerations for the study of EV function in metabolism.

Despite the high utility and widespread use of Cre driver lines, lack of Cre specificity, Cre-induced toxicity or poor experimental design can affect experimental results and conclusions. Such pitfalls must be considered before embarking on any Cre-based studies in metabolic research.

Time-restricted eating has become a popular diet for weight management and has spurred tremendous interest in the scientific community. The translation of results from TRE trials heavily depends on trial design. In this Comment, we provide general guidelines on optimizing the design and performance of time-restricted eating trials in human participants.

As a counterpoint to the increasing complexity and amount of data in manuscripts, we introduce Brief Communications as our shortest article type yet.

Recent technological advances permit the profiling of metabolic changes in single cells, which sheds light on how metabolism regulates immune responses. We advocate for accessible and standardized tools to reduce the barrier of entry to immunometabolism studies and facilitate the translation of fundamental findings towards clinical applications.

When preparing your manuscript, clear presentation of the data and concise writing are key. In this Editorial, we offer tips on how to better communicate your results.

Non-alcoholic liver disease (NAFLD) is now metabolic dysfunction-associated steatotic liver disease (MASLD), emphasizing the key metabolic factors of obesity, insulin resistance, vascular dysfunction and dyslipidaemia. Here, we discuss impacts on the existing body of clinical and preclinical liver disease research and on research moving forward.

Continuous glucose monitoring (CGM) is increasingly being used to collect and evaluate data on glycaemic control for research purposes. However, the use of CGM in research settings requires proper understanding and handling of these devices for correct data collection and interpretation.

The prevailing notion that mitochondrial diseases arise from ATP deficiency is challenged by recent evidence that oxidative phosphorylation defects trigger maladaptive stress responses consuming excess energy. We argue that this chronic state of hypermetabolism imposes energetic constraints, thus causing mitochondrial disease pathophysiology, calling for careful translational studies from organelle to organism.

The field of personalized nutrition hypothesizes that ‘big data’ — biological, behavioural, social and environmental — can be leveraged to make more precise and effective dietary recommendations to individuals for improving health outcomes, compared to generic dietary advice. This article describes the research questions that need to be answered to understand whether personalized nutrition brings additional clinical utility.

This month, Nature Metabolism turns five. For a young journal such as ours, this anniversary represents a milestone worth celebrating, and a welcome opportunity to look back.

Nature Metabolism is launching a joint collection of articles focusing on dietary interventions to improve cardiometabolic health, together with Nature Communications, npj Metabolic Health and Disease and Scientific Reports.

Here we reflect on touching points between basic science and clinical research, while highlighting key points to consider when submitting clinical work to our journal.

Subcellular quantitative analysis has been a long-standing goal of mass spectrometry imaging, but was originally thought to be unattainable. However, recent advances have made organelle-level absolute quantification through mass spectrometry imaging a reality, thanks to the development of nano secondary ion mass spectrometry.