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In the wake of devastating floods in the South of Brazil, researchers are working out how best to help people — plus, what concerns do Nature’s readers have about the US election.
Experiments using DNA barcoding for lineage tracing in mouse models of colorectal cancer reveal polyclonal origins of premalignant lesions, with a transition to monoclonality as they progress to the advanced tumour.
Laser spectroscopy measurements of the fermium isotopic chain show a smooth trend in the nuclear size of heavy actinide elements, and diminishing shell effects on the size evolution compared with lighter nuclei.
Multicolour lineage tracing and mutagenesis studies in a mouse model show that many intestinal tumours are polyclonal, with multiple clones exhibiting independent Apc mutations driven by differences in KRAS and MYC signalling.
Large-scale roll-to-roll-assisted blade coating is used in the production of scalable ultrastong MXene films with superior mechanical, electromagnetic shielding and bone regeneration properties.
A strategy using engineered functional customized viral receptors enables the development of functional infection models for coronaviruses whose native cellular receptors are unknown.
Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic signalling and assists healing.
Dynamic interface printing is a new form of 3D printing that leverages an acoustically modulated, constrained air–liquid boundary to rapidly generate centimetre-scale 3D structures within tens of seconds.
An analysis of 38 ancient genomes from the aurochs, the extinct ancestor of modern cattle, provides insight into the population ancestry and domestication of this species.
Analysis of bedrock elastic deformation using high-resolution observations from 22 Greenland GNSS Network stations shows that the Greenland ice sheet buffers enough summer meltwater englacially to cause subsidence of about 5 mm during the melt season.
Innate IL-17-producing T cells—in particular, adipose γδ17 T cells—are enriched in molecular-clock genes, and the circadian expression of IL-17A and RORγt by these cells has a role in maintaining local homeostasis and regulating lipogenesis.
We find that leptin-target neurons expressing basonuclin 2 in the arcuate nucleus that acutely suppress appetite by directly inhibiting agouti-related protein neurons are a key component of the neural circuit that maintains energy balance.
Using a multipurpose, single-cell CRISPR platform, we demonstrate precise timing of tissue-specific cell expansion during mouse embryonic development, unconventional developmental relationships between cell types, new epithelial progenitor states and insights into precancer initiation by leveraging genetic histories.
An alternative route to drive the transverse optical phonon softening sheds light on developing a unified theory for ferroelectricity enhancement in ultrathin films free from depolarization fields using ionic radius differences and strains, among other methods.
Visium spatial transcriptomics, single-nucleus RNA sequencing and co-detection by indexing are used to identify distinct spatial microregions in tumours and their microenvironment across six diverse solid cancer types.
