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Neuroendocrinology

Diabetes, IL-10 and the brain’s microvascular crisis

Nature Metabolism volume 6, pages 2029–2030 (2024)Cite this article

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A new study finds that capillary vessels become obstructed in diabetes and that their dysfunction may cause microvascular damage and lead to cognitive deficits. Such obstruction is independent of the elevated blood sugar found in diabetes and is triggered by elevated interleukin-10 cytokine signalling in cerebral blood vessel endothelial cells.

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Fig. 1: Sharma et al. report that elevated blood levels of the cytokine IL-10 contribute to capillary stalling within the brain.

References

  1. Clarke, D. D. & Sokoloff, L. in Basic Neurochemistry: Molecular, Cellular and Medical Aspects 6th edn (Lippincott-Raven, 1999).

  2. Sargent, S. M. et al. Vasc. Biol. 5, e230010 (2023).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Hartmann, D. A. et al. Nat. Neurosci. 24, 633–645 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Santisakultarm, T. P. et al. J. Thromb. Haemost. 12, 2120–2130 (2014).

    Article  CAS  PubMed  Google Scholar 

  5. Cruz Hernández, J. C. et al. Nat. Neurosci. 22, 413–420 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  6. El Amki, M. et al. Cell Rep. 33, 108260 (2020).

    Article  CAS  PubMed  Google Scholar 

  7. Li, Y. et al. Signal Transduct. Target. Ther. 8, 152 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Lacy, M. E. et al. Diabetes Care 41, 2339–2345 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Chandran, R. et al. Brain Res. 1749, 147132 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Wang, S. et al. Geroscience 42, 1387–1410 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Sharma, S. et al. Nat. Metab. https://doi.org/10.1038/s42255-024-01159-9 (2024).

  12. Chau, A. C. M. et al. Neuroimage Clin. 27, 102302 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Ouyang, W., Rutz, S., Crellin, N. K., Valdez, P. A. & Hymowitz, S. G. Annu. Rev. Immunol. 29, 71–109 (2011).

    Article  CAS  PubMed  Google Scholar 

  14. dos Santos Haber, J. F. et al. Biomedicines 11, 1120 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Sarabi, M. S. et al. Neuroimage 286, 120504 (2024).

    Article  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Celine E. Riera

  2. Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Celine E. Riera

  3. Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Celine E. Riera

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  1. Celine E. Riera
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Correspondence to Celine E. Riera.

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Riera, C.E. Diabetes, IL-10 and the brain’s microvascular crisis. Nat Metab 6, 2029–2030 (2024). https://doi.org/10.1038/s42255-024-01161-1

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