Extended Data Fig. 7: Abnormal distribution of H3K9 methylation in mutant iPSC-CMs.
From: Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy
a, b, Representative images of immunofluorescence staining of control mutant iPSC-CMs. iPSC-CMs were stained with specific antibodies against H3K9me2 or H3K9me3 (green). Blue, DAPI. Scale bar, 1,000 nm. The experiments were repeated three times independently with similar results. c–e, Representative images of lamin A/C enrichment and LAD distribution of ChIP–seq data. ChIP–qPCR analysis of H3K9me2 and H3K9me3 enrichment on LAD regions. Data are mean ± s.d.; n = 3.