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Collinge et al. reply

Nature volume 535, pages E2–E3 (2016)Cite this article

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REPLYING TO C. Feeney et al. Nature 535, 10.1038/nature18602 (2016)

In the accompanying Comment1 Feeney et al. argue that we have not excluded other explanations of our finding of extensive amyloid-β (Aβ) deposition in relatively young individuals who received extracts of human pituitary glands2. They argue that this may have been a consequence of their underlying pathology that led to cadaveric pituitary-derived human growth hormone (c-hGH) treatment and propose that growth hormone deficiency and Aβ pathology in these patients may have resulted from traumatic brain injury (TBI).

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References

  1. Feeney, C. et al. Seeds of neuroendocrine doubt. Nature 535, http://dx.doi.org/10.1038/nature18602 (2016)

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Authors and Affiliations

  1. Medical Research Council Prion Unit, Queen Square, London, WC1N 3BG, UK

    John Collinge, Simon Mead & Peter Rudge

  2. Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK

    John Collinge, Simon Mead & Sebastian Brandner

  3. National Prion Clinic, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, WC1N 3BG, UK

    John Collinge, Simon Mead & Peter Rudge

  4. Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, WC1N 3BG, UK

    Zane Jaunmuktane & Sebastian Brandner

Authors
  1. John Collinge
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  2. Zane Jaunmuktane
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  3. Simon Mead
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  4. Peter Rudge
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  5. Sebastian Brandner
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Correspondence to Sebastian Brandner.

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Collinge, J., Jaunmuktane, Z., Mead, S. et al. Collinge et al. reply. Nature 535, E2–E3 (2016). https://doi.org/10.1038/nature18603

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