Pituitary diseases articles from across Nature Portfolio

Patients with acromegaly are commonly affected by diabetes mellitus, which occurs as a complication of growth hormone hypersecretion. This Review discusses the pathophysiology of diabetes mellitus in acromegaly and explores management options in these patients.

Central diabetes insipidus has been renamed as arginine vasopressin deficiency. This Review discusses advances in diagnosis and management of arginine vasopressin deficiency. In addition, the possibility of oxytocin deficiency in these patients is considered, as well as oxytocin provocation testing and the future therapeutic potential of oxytocin replacement.

Iatrogenic adrenal insufficiency (IAI) is the most common form of adrenal insufficiency in adult patients. This comprehensive Review aims to aid clinicians in identifying who is at risk of IAI, how to approach screening of at-risk populations and how to treat patients with IAI.

This Consensus Statement, which is endorsed by the Pituitary Society, offers evidence-based graded consensus recommendations and key summary points for clinical practice on the diagnosis and management of prolactinomas.

This Review discusses challenges in the management of Cushing disease in adults and provides information to help with planning an integrated and individualized approach for each patient.

A new study convincingly demonstrates a deficiency of pituitary oxytocin secretion in patients with vasopressin deficiency. Neuropsychological evaluations of these patients indicate increased anxiety and reduced prosocial behaviours, thereby characterizing the phenotype of the first documented disorder of oxytocin deficiency in humans.