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KEGG   Homo sapiens (human): 915
Entry
915               CDS       T01001                                 
Symbol
CD3D, CD3-DELTA, CD3DELTA, IMD19, T3D
Name
(RefSeq) CD3 delta subunit of T-cell receptor complex
  KO
K06450  T-cell surface glycoprotein CD3 delta chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04640  Hematopoietic cell lineage
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa05142  Chagas disease
hsa05162  Measles
hsa05166  Human T-cell leukemia virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05340  Primary immunodeficiency
Network
nt06183  Yersinia
nt06537  TCR/BCR signaling
  Element
N01106  TCR-PLCG-ITPR signaling pathway
Disease
H00091  T-B+Severe combined immunodeficiency
Drug target
Antithymocyte immunoglobulin (rabbit): D09190<JP/US>
Blinatumomab: D09325<JP/US>
Catumaxomab: D09207
Flotetuzumab: D11306
Muromonab-CD3: D05092
Otelixizumab: D08959
Tebentafusp: D12296<US>
Teplizumab: D09013<US>
Visilizumab: D06314
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    915 (CD3D)
   04660 T cell receptor signaling pathway
    915 (CD3D)
   04658 Th1 and Th2 cell differentiation
    915 (CD3D)
   04659 Th17 cell differentiation
    915 (CD3D)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    915 (CD3D)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    915 (CD3D)
   05170 Human immunodeficiency virus 1 infection
    915 (CD3D)
   05162 Measles
    915 (CD3D)
   05169 Epstein-Barr virus infection
    915 (CD3D)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    915 (CD3D)
  09163 Immune disease
   05340 Primary immunodeficiency
    915 (CD3D)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    915 (CD3D)
CD molecules [BR:hsa04090]
 Proteins
  915 (CD3D)
SSDB
Motif
Pfam: Ig_4 ITAM Ig_5 DAP10
Other DBs
NCBI-GeneID: 915
NCBI-ProteinID: NP_000723
OMIM: 186790
HGNC: 1673
Ensembl: ENSG00000167286
UniProt: P04234 B0YIY4
Structure
LinkDB
Position
11:complement(118338954..118342705)
AA seq 171 aa
MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDL
GKRILDPRGIYRCNGTDIYKDKESTVQVHYRMCQSCVELDPATVAGIIVTDVIATLLLAL
GVFCFAGHETGRLSGAADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK
NT seq 516 nt   +upstreamnt  +downstreamnt
atggaacatagcacgtttctctctggcctggtactggctacccttctctcgcaagtgagc
cccttcaagatacctatagaggaacttgaggacagagtgtttgtgaattgcaataccagc
atcacatgggtagagggaacggtgggaacactgctctcagacattacaagactggacctg
ggaaaacgcatcctggacccacgaggaatatataggtgtaatgggacagatatatacaag
gacaaagaatctaccgtgcaagttcattatcgaatgtgccagagctgtgtggagctggat
ccagccaccgtggctggcatcattgtcactgatgtcattgccactctgctccttgctttg
ggagtcttctgctttgctggacatgagactggaaggctgtctggggctgccgacacacaa
gctctgttgaggaatgaccaggtctatcagcccctccgagatcgagatgatgctcagtac
agccaccttggaggaaactgggctcggaacaagtga

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