| Calcium signaling |
| N01106 |
(TCR+CD3+CD4) | → | (LCK,FYN,ZAP70) | → | (SLP76+GADS+LAT+VA.. | → | PLCG | → | IP3 | → | ITPR | → | Ca2+(cyto) |
| N01107 |
YopH | ⊣ | LCK |
| N01108 |
| | YopH | ⊣ | (SLP76,LAT,VAV) |
| | | |
| TLR signaling |
| N00435 |
(TLR1,TLR2,TLR4) | → | (TIRAP+MYD88) | → | (IRAK4+IRAK1) | → | (TRAF6+TAK1+TAB2) | → | IKK | → | NFKBIA | → | NFKB | ⇒ | (TNF,IL6,IL12A,IL1.. |
| N00859 |
| | | | YopP/J | ⊣ | (TRAF6+TRAF2+TAK1+.. |
| N00438 |
(TLR2,TLR4) | → | (TIRAP+MYD88) | → | (IRAK4+IRAK1) | → | (TRAF6+TAK1+TAB2) | → | (MEK,MKK3/6,MKK4/7.. | → | (ERK,p38,JNK) | → | AP1 |
| N00862 |
| | | | | | YopP/J | ⊣ | (MEK,MKK3/6,MKK4/7.. |
| | | |
| NLR signaling |
| N00742 |
| | (NLRP3+PYCARD) | → | CASP1 | → | (IL1B,IL18,IL33) |
| N00864 |
YopK | ⊣ | (NLRP3+PYCARD) |
| N00863 |
| | YopM | ⊣ | CASP1 |
| N00867 |
| | (NLRC4+PYCARD) | → | CASP1 | → | (IL1B,IL18) |
| N00865 |
YopK | ⊣ | (NLRC4+PYCARD) |
| N01570 |
| | PSTPIP1 | → | MEFV |
| N00866 |
YopM | → | (PKN1,PKN2) | ⊣ | (MEFV+PYCARD) |
| | | |
| Cytoskeletal regulation |
| N01072 |
FN1 | → | (ITGA+ITGB) | → | PTK2 | → | ARHGEF28 | → | RHOA |
| N01098 |
| | | | | | YopT | ⊣ | RHOA |
| N01099 |
| | | | | | YopE | ⊣ | RHOA |
| N01104 |
LPA | → | LPAR | → | (GNAQ,GNA11) | → | ARHGEF12 | → | RHOA |
| N01105 |
| | YpkA | ⊣ | GNAQ |
| N01068 |
FN1 | → | (ITGA+ITGB) | → | (SRC,PTK2) | → | (PXN,CRK+BCAR1) | → | (DOCK1+ELMO1) | → | RAC |
| N01111 |
| | YopH | ⊣ | PTK2 |
| N01109 |
| | | | YopH | ⊣ | PXN |
| N01110 |
| | | | YopH | ⊣ | BCAR1 |
| N00951 |
FN1 | → | (ITGA+ITGB) | → | RHOG | → | (DOCK1+ELMO) | → | RAC |
| N01100 |
| | YopE | ⊣ | RHOG |
| N01101 |
| | YopT | ⊣ | RHOG |
| N01102 |
| | | | | | YopE | ⊣ | RAC1 |
| N01090 |
IGG | → | FCGR | → | CRK | → | DOCK1 | → | RAC |
| N01103 |
| | | | | | YpkA | ⊣ | RAC |
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