KEGG T01001: 3033

Homo sapiens (human): 3033

Entry

3033              CDS       T01001

Symbol

HADH, HAD, HADH1, HADHSC, HCDH, HHF4, MSCHAD, SCHAD

Name

(RefSeq) hydroxyacyl-CoA dehydrogenase

K00022

3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]

Organism

hsa Homo sapiens (human)

Pathway

hsa00062

Fatty acid elongation

hsa00071

Fatty acid degradation

hsa00280

Valine, leucine and isoleucine degradation

hsa00310

Lysine degradation

hsa00380

Tryptophan metabolism

hsa00650

Butanoate metabolism

hsa01100

Metabolic pathways

hsa01212

Fatty acid metabolism

Module

hsa_M00032

Lysine degradation, lysine => saccharopine => acetoacetyl-CoA

hsa_M00085

Fatty acid elongation in mitochondria

hsa_M00087

beta-Oxidation

Network

nt06020 beta-Oxidation in mitochondria
nt06024 Valine, leucine and isoleucine degradation

Element

N00804

beta-Oxidation

N00856

Isoleucine degradation

Disease

H00525

Disorders of mitochondrial fatty-acid oxidation

H01267

Familial hyperinsulinemic hypoglycemia

H01364

3-Hydroxyacyl-CoA dehydrogenase deficiency

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00650 Butanoate metabolism
    3033 (HADH)
  09103 Lipid metabolism
   00062 Fatty acid elongation
    3033 (HADH)
   00071 Fatty acid degradation
    3033 (HADH)
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    3033 (HADH)
   00310 Lysine degradation
    3033 (HADH)
   00380 Tryptophan metabolism
    3033 (HADH)
Enzymes [BR:hsa01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35  3-hydroxyacyl-CoA dehydrogenase
     3033 (HADH)

SSDB

Motif

Pfam:

3HCDH_N 3HCDH Pyr_redox_2 UDPG_MGDP_dh_N DAO Pyr_redox NAD_Gly3P_dh_N NAD_binding_2 NAD_binding_8 AlaDh_PNT_C F420_oxidored 2-Hacid_dh_C NAD_binding_7 HI0933_like Sacchrp_dh_NADP TrkA_N GIDA FAD_binding_3 XdhC_C

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

4:107989889..108035171

AA seq 314 aa
MAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTE
DILAKSKKGIEESLRKVAKKKFAENLKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAI
VENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPVMKL
VEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYERGDAS
KEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWHEMDAENPLHQPSPSLNKLVAEN
KFGKKTGEGFYKYK

NT seq 945 nt +upstreamnt +downstreamnt
atggccttcgtcaccaggcagttcatgcgttccgtgtcctcctcgtccaccgcctcggcc
tcggccaagaagataatcgtcaagcacgtgacggtcatcggcggcgggctgatgggcgcc
ggcattgcccaggttgctgcagcaactggtcacacagtagtgttggtagaccagacagag
gacatcctggcaaaatccaaaaagggaattgaggaaagccttaggaaagtggcaaagaag
aagtttgcagaaaaccttaaggccggcgatgaatttgtggagaagaccctgagcaccata
gcgaccagcacggatgcagcctccgttgtccacagcacagacttggtggtggaagccatc
gtggagaatctgaaggtgaaaaacgagctcttcaaaaggctggacaagtttgctgctgaa
catacaatctttgccagcaacacttcctccttgcagattacaagcatagctaatgccacc
accagacaagaccgattcgctggcctccatttcttcaacccagtgcctgtcatgaaactt
gtggaggtcattaaaacaccaatgaccagccagaagacatttgaatctttggtagacttt
agcaaagccctaggaaagcatcctgtttcttgcaaggacactcctgggtttattgtgaac
cgcctcctggttccatacctcatggaagcaatcaggctgtatgaacgaggtgacgcatcc
aaagaagacattgacactgctatgaaattaggagccggttaccccatgggcccatttgag
cttctagattatgtcggactggatactacgaagttcatcgtggatgggtggcatgaaatg
gatgcagagaacccattacatcagcccagcccatccttaaataagctggtagcagagaac
aagttcggcaagaagactggagaaggattttacaaatacaagtga

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