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KEGG   NETWORK: N01657
Entry
N01657                      Network                                
Name
GPCR-PI3K signaling pathway
Definition
(GPCR+GNB+GNG) -> PI3Kgamma -> PIP3 -> AKT
  Expanded
((10161,1128,1129,1902,2149,23566,2846,57121,9170)+(2782,2783,2784,59345,10681)+(54331,2785,2786,2787,2788,94235,2790,2791,55970,51764,2792,2793)) -> (5294+(23533,146850)) -> C05981 -> (207,208,10000)
Class
nt06530 PI3K signaling
Type
Reference
Pathway
hsa04151  PI3K-Akt signaling pathway
Gene
2149  F2R; coagulation factor II thrombin receptor
1128  CHRM1; cholinergic receptor muscarinic 1
1129  CHRM2; cholinergic receptor muscarinic 2
1902  LPAR1; lysophosphatidic acid receptor 1
9170  LPAR2; lysophosphatidic acid receptor 2
23566  LPAR3; lysophosphatidic acid receptor 3
2846  LPAR4; lysophosphatidic acid receptor 4
57121  LPAR5; lysophosphatidic acid receptor 5
10161  LPAR6; lysophosphatidic acid receptor 6
2782  GNB1; G protein subunit beta 1
2783  GNB2; G protein subunit beta 2
2784  GNB3; G protein subunit beta 3
59345  GNB4; G protein subunit beta 4
10681  GNB5; G protein subunit beta 5
54331  GNG2; G protein subunit gamma 2
2785  GNG3; G protein subunit gamma 3
2786  GNG4; G protein subunit gamma 4
2787  GNG5; G protein subunit gamma 5
2788  GNG7; G protein subunit gamma 7
94235  GNG8; G protein subunit gamma 8
2790  GNG10; G protein subunit gamma 10
2791  GNG11; G protein subunit gamma 11
55970  GNG12; G protein subunit gamma 12
51764  GNG13; G protein subunit gamma 13
2792  GNGT1; G protein subunit gamma transducin 1
2793  GNGT2; G protein subunit gamma transducin 2
5294  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
23533  PIK3R5; phosphoinositide-3-kinase regulatory subunit 5
146850  PIK3R6; phosphoinositide-3-kinase regulatory subunit 6
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:35322259
  Authors
Lanahan SM, Wymann MP, Lucas CL
  Title
The role of PI3Kgamma in the immune system: new insights and translational implications.
  Journal
Nat Rev Immunol 22:687-700 (2022)
DOI:10.1038/s41577-022-00701-8
Reference
PMID:31443495
  Authors
Buchanan CM, Lee KL, Shepherd PR
  Title
For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors.
  Journal
Biomolecules 9:biom9090402 (2019)
DOI:10.3390/biom9090402
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