KEGG DRUG: Pioglitazone hydrochloride and glimepiride tablets

DRUG: Pioglitazone hydrochloride and glimepiride tablets

Entry

D09848            Mixture   Drug

Name

Pioglitazone hydrochloride and glimepiride tablets (JP18);
Pioglitazone and glimepiride;
Duetact;
Sonias (TN)

Product

DUETACT (Takeda Pharmaceuticals America)

Generic

PIOGLITAZONE AND GLIMEPIRIDE (Prasco Laboratories), PIOGLITAZONE HYDROCHLORIDE AND GLIMEPIRIDE (Sandoz)

Component

(Pioglitazone hydrochloride [DR:D00945] | Pioglitazone [DR:D08378]), Glimepiride [DR:D00593]

Class

Antidiabetic agent
DG02044  Hypoglycemic agent
Metabolizing enzyme substrate
DG02918  CYP2C8 substrate
DG01642  CYP2C9 substrate

Remark

Therapeutic category:

3969

ATC code:

A10BD06

Product:

D09848<JP/US>

Efficacy

Antidiabetic

Disease

Type 2 diabetes mellitus [DS:H00409]

Comment

Pioglitazone is primarily metabolized by CYP2C8.
Glimepiride is primarily metabolized by CYP2C9.

Metabolism

Enzyme: CYP2C8 [HSA:1558], CYP2C9 [HSA:1559]

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BD Combinations of oral blood glucose lowering drugs
     A10BD06 Glimepiride and pioglitazone
      D09848  Pioglitazone hydrochloride and glimepiride tablets (JP18) <JP/US>
USP drug classification [BR:br08302]
Blood Glucose Regulators
  Antidiabetic Combinations
   Glimepiride/ Pioglitazone Hydrochloride
    D09848  Pioglitazone hydrochloride and glimepiride tablets (JP18)
Therapeutic category of drugs in Japan [BR:br08301]
3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D09848  Pioglitazone hydrochloride and glimepiride tablets (JP18)
Drug groups [BR:br08330]
Antidiabetic agent
  DG02044  Hypoglycemic agent
   D09848  Pioglitazone hydrochloride and glimepiride tablets
Metabolizing enzyme substrate
  DG02918  CYP2C8 substrate
   D09848  Pioglitazone hydrochloride and glimepiride tablets
  DG01642  CYP2C9 substrate
   D09848  Pioglitazone hydrochloride and glimepiride tablets
Drug classes [BR:br08332]
Antidiabetic agent
  DG02044  Hypoglycemic agent
   D09848  Pioglitazone hydrochloride and glimepiride tablets
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D09848  Pioglitazone hydrochloride and glimepiride tablets
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D09848
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D09848

Other DBs

PubChem:

124490587

LinkDB

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