The 2022 Alsco Uniforms 300 was the third stock car race of the 2022 NASCAR Xfinity Series and the 26th iteration of the event. The race was held on Saturday, March 5, 2022, in North Las Vegas, Nevada at Las Vegas Motor Speedway, a 1.5 miles (2.4 km) permanent D-shaped oval racetrack. The race was run over 200 laps. Ty Gibbs of Joe Gibbs Racing would win the race after taking the lead on the final restart. This was Gibbs' fifth career Xfinity Series win, and his first of the season. To fill out the podium, Noah Gragson of JR Motorsports and Daniel Hemric of Kaulig Racing would finish second and third, respectively.