About: Tiamenidine

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Tiamenidine (BAN, USAN, INN, also known as thiamenidine, Hoe 440) is an imidazoline compound that shares many of the pharmacological properties of clonidine. It is a centrally-acting α2 adrenergic receptor agonist (IC50 = 9.1 nM). It also acts as an α1-adrenergic receptor agonist to a far lesser extent (IC50 = 4.85 μM). In hypertensive volunteers, like clonidine, it significantly increased sinus node recovery time and lowered cardiac output. It was marketed (as tiamenidine hydrochloride) by Sanofi-Aventis under the brand name Sundralen for the management of essential hypertension.

Property	Value
dbo:abstract	Tiamenidine (BAN, USAN, INN, also known as thiamenidine, Hoe 440) is an imidazoline compound that shares many of the pharmacological properties of clonidine. It is a centrally-acting α2 adrenergic receptor agonist (IC50 = 9.1 nM). It also acts as an α1-adrenergic receptor agonist to a far lesser extent (IC50 = 4.85 μM). In hypertensive volunteers, like clonidine, it significantly increased sinus node recovery time and lowered cardiac output. It was marketed (as tiamenidine hydrochloride) by Sanofi-Aventis under the brand name Sundralen for the management of essential hypertension. (en)
dbo:alternativeName	Sundralen, Symcorad, Symcor (en)
dbo:casNumber	31428-61-2
dbo:chEMBL	295409
dbo:fdaUniiCode	195V08O55G
dbo:kegg	D06127
dbo:pubchem	39974
dbo:thumbnail	wiki-commons:Special:FilePath/Tiamenidine.svg?width=300
dbo:wikiPageID	27152134 (xsd:integer)
dbo:wikiPageLength	4986 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1120041740 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Cardiac_output dbc:Abandoned_drugs dbc:Alpha-2_adrenergic_receptor_agonists dbc:Chloroarenes dbc:Imidazolines dbr:Essential_hypertension dbr:Clonidine dbr:Tizanidine dbr:Agonist dbc:Alpha-1_adrenergic_receptor_agonists dbr:Alpha-1_adrenergic_receptor dbr:Alpha-2_adrenergic_receptor dbr:Ethylenediamine dbr:British_Approved_Name dbr:Central_nervous_system dbc:Thiophenes dbr:International_Nonproprietary_Name dbc:Antihypertensive_agents dbr:Methyl_iodide dbr:United_States_Adopted_Name dbr:IC50 dbr:Imidazoline dbr:Sanofi-Aventis dbr:File:Tiamenidine-synthesis.svg
dbp:atcPrefix	2.0 (dbd:nicaraguanCórdoba)
dbp:atcSuffix	AC (en)
dbp:c	8 (xsd:integer)
dbp:casNumber	31428 (xsd:integer)
dbp:chembl	295409 (xsd:integer)
dbp:chemspiderid	36548 (xsd:integer)
dbp:cl	1 (xsd:integer)
dbp:eliminationHalfLife	-18000.0 (dbd:second)
dbp:h	10 (xsd:integer)
dbp:iupacName	N--4,5-dihydro-1H-imidazol-2-amine (en)
dbp:kegg	D06127 (en)
dbp:n	3 (xsd:integer)
dbp:pubchem	39974 (xsd:integer)
dbp:s	1 (xsd:integer)
dbp:smiles	Clc2sccC (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	CVWILQHZFWRYPB-UHFFFAOYSA-N (en)
dbp:tradename	Sundralen, Symcorad, Symcor (en)
dbp:unii	195 (xsd:integer)
dbp:verifiedfields	changed (en)
dbp:verifiedrevid	470609987 (xsd:integer)
dbp:watchedfields	changed (en)
dbp:width	180 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Adrenergic_receptor_modulators dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Keggcite dbt:Stdinchicite dbt:Antihypertensives_and_diuretics
dct:subject	dbc:Abandoned_drugs dbc:Alpha-2_adrenergic_receptor_agonists dbc:Chloroarenes dbc:Imidazolines dbc:Alpha-1_adrenergic_receptor_agonists dbc:Thiophenes dbc:Antihypertensive_agents
gold:hypernym	dbr:Compound
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatAntihypertensiveAgents yago:WikicatMolecularFormulas yago:Abstraction100002137 yago:Agent109190918 yago:CausalAgent100007347 yago:Communication100033020 yago:Formula106816935 yago:Message106598915 yago:MolecularFormula106817173 yago:PhysicalEntity100001930 dbo:ChemicalCompound dbo:Drug yago:Statement106722453
rdfs:comment	Tiamenidine (BAN, USAN, INN, also known as thiamenidine, Hoe 440) is an imidazoline compound that shares many of the pharmacological properties of clonidine. It is a centrally-acting α2 adrenergic receptor agonist (IC50 = 9.1 nM). It also acts as an α1-adrenergic receptor agonist to a far lesser extent (IC50 = 4.85 μM). In hypertensive volunteers, like clonidine, it significantly increased sinus node recovery time and lowered cardiac output. It was marketed (as tiamenidine hydrochloride) by Sanofi-Aventis under the brand name Sundralen for the management of essential hypertension. (en)
rdfs:label	Tiamenidine (en)
owl:sameAs	freebase:Tiamenidine yago-res:Tiamenidine wikidata:Tiamenidine dbpedia-fa:Tiamenidine dbpedia-sh:Tiamenidine dbpedia-sr:Tiamenidine https://global.dbpedia.org/id/4wbMg
prov:wasDerivedFrom	wikipedia-en:Tiamenidine?oldid=1120041740&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Tiamenidine-synthesis.svg wiki-commons:Special:FilePath/Tiamenidine.svg
foaf:isPrimaryTopicOf	wikipedia-en:Tiamenidine
is dbo:wikiPageRedirects of	dbr:C8H10ClN3S
is dbo:wikiPageWikiLink of	dbr:C8H10ClN3S dbr:Alpha-1_adrenergic_receptor dbr:Alpha-2_adrenergic_receptor dbr:List_of_drugs:_Ti
is foaf:primaryTopic of	wikipedia-en:Tiamenidine