About: Terodiline

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Terodiline is a drug used in urology as an antispasmodic. It relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is probably due to its anticholinergic and calcium antagonist activity. However, it also blocks IKr (Kv11.1) channels (see hERG gene) so can pose a risk for torsades de pointes. This cardiotoxicity is concentration dependent.

Property	Value
dbo:abstract	Terodiline is a drug used in urology as an antispasmodic. It relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is probably due to its anticholinergic and calcium antagonist activity. However, it also blocks IKr (Kv11.1) channels (see hERG gene) so can pose a risk for torsades de pointes. This cardiotoxicity is concentration dependent. (en)
dbo:casNumber	(hydrochloride) 15793-40-5
dbo:chEMBL	363295
dbo:fdaUniiCode	70KG06964W
dbo:pubchem	23480
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dbo:wikiPageWikiLink	dbr:Antispasmodic dbc:Amines dbr:Urology dbr:Torsades_de_pointes dbr:HERG dbc:Muscarinic_antagonists dbc:Tert-butyl_compounds
dbp:atcPrefix	G04 (en)
dbp:atcSuffix	BD05 (en)
dbp:c	20 (xsd:integer)
dbp:casNumber	15793 (xsd:integer)
dbp:chembl	363295 (xsd:integer)
dbp:chemspiderid	21952 (xsd:integer)
dbp:h	27 (xsd:integer)
dbp:iupacName	N-tert-butyl-4,4-dibutan-2-amine (en)
dbp:n	1 (xsd:integer)
dbp:pubchem	23480 (xsd:integer)
dbp:smiles	c1ccccc1CCCC (en)
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dbp:stdinchikey	UISARWKNNNHPGI-UHFFFAOYSA-N (en)
dbp:unii	70 (xsd:integer)
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dcterms:subject	dbc:Amines dbc:Muscarinic_antagonists dbc:Tert-butyl_compounds
gold:hypernym	dbr:Drug
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rdfs:comment	Terodiline is a drug used in urology as an antispasmodic. It relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is probably due to its anticholinergic and calcium antagonist activity. However, it also blocks IKr (Kv11.1) channels (see hERG gene) so can pose a risk for torsades de pointes. This cardiotoxicity is concentration dependent. (en)
rdfs:label	Terodiline (en)
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