About: Ralfinamide

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Ralfinamide (INN) (code names NW-1029, FCE-26742A, PNU-0154339E) is a multimodal drug which is under investigation by for the treatment of neuropathic pain and other pain conditions such as post-operative dental pain. It has a relatively complex pharmacology, acting as a mixed voltage-gated sodium channel blocker (including Nav1.7), N-type calcium channel blocker, noncompetitive NMDA receptor antagonist, and monoamine oxidase B inhibitor.

Property	Value
dbo:abstract	Ralfinamide (INN) (code names NW-1029, FCE-26742A, PNU-0154339E) is a multimodal drug which is under investigation by for the treatment of neuropathic pain and other pain conditions such as post-operative dental pain. It has a relatively complex pharmacology, acting as a mixed voltage-gated sodium channel blocker (including Nav1.7), N-type calcium channel blocker, noncompetitive NMDA receptor antagonist, and monoamine oxidase B inhibitor. It has thus far progressed as far as phase IIb/phase III clinical trials. In 2010 it failed a phase II trial for lower back pain. Encouraging Phase II results have been announced for neuropathic pain. (en)
dbo:casNumber	133865-88-0
dbo:chEMBL	2107771
dbo:fdaUniiCode	3LPF0S0GVV
dbo:pubchem	5745207
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dbp:atcPrefix	None (en)
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dbp:iupacName	N2-{4-[oxy]benzyl}-L-alaninamide (en)
dbp:n	2 (xsd:integer)
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dbp:pubchem	5745207 (xsd:integer)
dbp:smiles	C[C@@H]NCc1cccOCc2ccccc2F (en)
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dbp:stdinchikey	BHJIBOFHEFDSAU-LBPRGKRZSA-N (en)
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rdfs:comment	Ralfinamide (INN) (code names NW-1029, FCE-26742A, PNU-0154339E) is a multimodal drug which is under investigation by for the treatment of neuropathic pain and other pain conditions such as post-operative dental pain. It has a relatively complex pharmacology, acting as a mixed voltage-gated sodium channel blocker (including Nav1.7), N-type calcium channel blocker, noncompetitive NMDA receptor antagonist, and monoamine oxidase B inhibitor. (en)
rdfs:label	Ralfinamide (en)
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