About: RU-58841

Property	Value
dbo:abstract	RU-58841, also known as PSK-3841 or HMR-3841, is a nonsteroidal antiandrogen (NSAA) which was initially developed in the 1980s by Roussel Uclaf, the French pharmaceutical company from which it received its name. It was formerly under investigation by ProStrakan (previously ProSkelia and Strakan) for potential use as a topical treatment for androgen-dependent conditions including acne, pattern hair loss, and excessive hair growth. The compound is similar in structure to the NSAA RU-58642 but contains a different side-chain. These compounds are similar in chemical structure to nilutamide, which is related to flutamide, bicalutamide, and enzalutamide, all of which are NSAAs similarly. RU-58841 can be synthesized either by building the hydantoin moiety or by aryl coupling to 5,5-dimethylhydantoin. RU-58841 produces cyanonilutamide (RU-56279) and RU-59416 as metabolites in animals. Cyanonilutamide has relatively low affinity for the androgen receptor but shows significant antiandrogenic activity in animals. RU-59416 has very low affinity for the androgen receptor. (en)
dbo:casNumber	154992-24-2
dbo:chEMBL	9337
dbo:class	dbr:Nonsteroidal_antiandrogen
dbo:fdaUniiCode	0D8FJQ0ADW
dbo:pubchem	132981
dbo:thumbnail	wiki-commons:Special:FilePath/RU-58841_structure.svg?width=300
dbo:wikiPageExternalLink	https://www.ingentaconnect.com/content/govi/pharmaz/2005/00000060/00000001/art00002
dbo:wikiPageID	42552728 (xsd:integer)
dbo:wikiPageLength	6597 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1103020512 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Roussel_Uclaf dbr:Moiety_(chemistry) dbr:Metabolite dbr:Bicalutamide dbr:Androgen-dependent_condition dbr:Hydantoin dbc:Abandoned_drugs dbc:Primary_alcohols dbc:Trifluoromethyl_compounds dbr:Chemical_structure dbr:Chemical_synthesis dbr:RU-56187 dbr:RU-59063 dbr:Enzalutamide dbr:Antiandrogen dbc:Hair_loss_medications dbc:Hair_removal dbc:Nonsteroidal_antiandrogens dbc:Hydantoins dbr:Cyanonilutamide dbr:Flutamide dbr:Nilutamide dbc:Nitriles dbr:Hirsutism dbr:Coupling_reaction dbc:Anti-acne_preparations dbr:Acne dbr:RU-57073 dbr:RU-58642 dbr:Topical_medication dbr:Side_chain dbr:Nonsteroidal_antiandrogen dbr:Pattern_hair_loss dbr:Aryl_group
dbp:c	17 (xsd:integer)
dbp:casNumber	154992 (xsd:integer)
dbp:chembl	9337 (xsd:integer)
dbp:chemspiderid	117358 (xsd:integer)
dbp:class	dbr:Nonsteroidal_antiandrogen
dbp:f	3 (xsd:integer)
dbp:h	18 (xsd:integer)
dbp:iupacName	4 (xsd:integer)
dbp:n	3 (xsd:integer)
dbp:o	3 (xsd:integer)
dbp:pubchem	132981 (xsd:integer)
dbp:smiles	CC1C (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	ARBYGDBJECGMGA-UHFFFAOYSA-N (en)
dbp:synonyms	PSK-3841; HMR-3841 (en)
dbp:unii	0 (xsd:integer)
dbp:width	250 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Androgen_receptor_modulators dbt:Cite_journal dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Fdacite
dct:subject	dbc:Abandoned_drugs dbc:Primary_alcohols dbc:Trifluoromethyl_compounds dbc:Hair_loss_medications dbc:Hair_removal dbc:Nonsteroidal_antiandrogens dbc:Hydantoins dbc:Nitriles dbc:Anti-acne_preparations
gold:hypernym	dbr:Candidate
rdf:type	owl:Thing dbo:Person dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:Agent114778436 yago:Anticonvulsant102718469 yago:CausalAgent100007347 yago:Drug103247620 yago:Hydantoin103550533 yago:Matter100020827 yago:Medicine103740161 yago:PhysicalEntity100001930 yago:WikicatHydantoins dbo:Drug yago:Substance100020090
rdfs:comment	RU-58841, also known as PSK-3841 or HMR-3841, is a nonsteroidal antiandrogen (NSAA) which was initially developed in the 1980s by Roussel Uclaf, the French pharmaceutical company from which it received its name. It was formerly under investigation by ProStrakan (previously ProSkelia and Strakan) for potential use as a topical treatment for androgen-dependent conditions including acne, pattern hair loss, and excessive hair growth. The compound is similar in structure to the NSAA RU-58642 but contains a different side-chain. These compounds are similar in chemical structure to nilutamide, which is related to flutamide, bicalutamide, and enzalutamide, all of which are NSAAs similarly. RU-58841 can be synthesized either by building the hydantoin moiety or by aryl coupling to 5,5-dimethylhydant (en)
rdfs:label	RU-58841 (en)
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prov:wasDerivedFrom	wikipedia-en:RU-58841?oldid=1103020512&ns=0
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