Issac Sewell (September 9, 1903 – August 20, 1990) was an American athlete, businessman, entrepreneur, and founder of the Uno Chicago Grill restaurant chain that originated in Chicago, Illinois, as well as founder of the Pizzeria Uno and Pizzeria Due restaurants there in 1943 and 1955, respectively. Sewell started as an All-Southwestern Conference guard as a player on the Texas Longhorn football teams from 1926 to 1929.