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- El col·lagen tipus VI és una forma de col·lagen principalment associada amb la matriu extracel·lular del múscul esquelètic. Està associat amb els gens , i . Els seus defectes estan associats amb la i la . (ca)
- Collagen VI (ColVI) is a type of collagen primarily associated with the extracellular matrix of skeletal muscle. ColVI maintains regularity in muscle function and stabilizes the cell membrane. It is synthesized by a complex, multistep pathway that leads to the formation of a unique network of linked microfilaments located in the extracellular matrix (ECM). ColVI plays a vital role in numerous cell types, including chondrocytes, neurons, myocytes, fibroblasts, and cardiomyocytes. ColVI molecules are made up of three alpha chains: α1(VI), α2(VI), and α3(VI). It is encoded by 6 genes: COL6A1, COL6A2, COL6A3, COL6A4, COL6A5, and COL6A6. The chain lengths of α1(VI) and α2(VI) are about 1,000 amino acids. The chain length of α3(VI) is roughly a third larger than those of α1(VI) and α2(VI), and it consists of several spliced variants within the range of 2,500 to 3,100 amino acids. The first two alpha chains subunits of ColVI have a molecular weight of 140-150 KDa and the third polypeptide chain is larger with a molecular weight of 250-300kDa. ColVI is also found in the skin, lungs, blood vessels, cornea and intervertebral disc. It also forms part of the peripheral nerves, brain, myocardium and adipose tissue. (en)
- Le collagène VI est une forme de collagène principalement associée à la matrice extracellulaire du muscle squelettique. Il constitue une famille de protéines dont les membres ont les gènes COL6A1 (en) 120220 , COL6A2 (en) 120240 , COL6A3 (en) 120250 qui sont localisées sur les chromosomes 21 (COL6A1, COL6A2) et 2, COL6A4, COL6A5, COL6A6, ces trois derniers étant situés sur le chromosome 6. (fr)
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| rdfs:comment
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- El col·lagen tipus VI és una forma de col·lagen principalment associada amb la matriu extracel·lular del múscul esquelètic. Està associat amb els gens , i . Els seus defectes estan associats amb la i la . (ca)
- Le collagène VI est une forme de collagène principalement associée à la matrice extracellulaire du muscle squelettique. Il constitue une famille de protéines dont les membres ont les gènes COL6A1 (en) 120220 , COL6A2 (en) 120240 , COL6A3 (en) 120250 qui sont localisées sur les chromosomes 21 (COL6A1, COL6A2) et 2, COL6A4, COL6A5, COL6A6, ces trois derniers étant situés sur le chromosome 6. (fr)
- Collagen VI (ColVI) is a type of collagen primarily associated with the extracellular matrix of skeletal muscle. ColVI maintains regularity in muscle function and stabilizes the cell membrane. It is synthesized by a complex, multistep pathway that leads to the formation of a unique network of linked microfilaments located in the extracellular matrix (ECM). ColVI plays a vital role in numerous cell types, including chondrocytes, neurons, myocytes, fibroblasts, and cardiomyocytes. ColVI molecules are made up of three alpha chains: α1(VI), α2(VI), and α3(VI). It is encoded by 6 genes: COL6A1, COL6A2, COL6A3, COL6A4, COL6A5, and COL6A6. The chain lengths of α1(VI) and α2(VI) are about 1,000 amino acids. The chain length of α3(VI) is roughly a third larger than those of α1(VI) and α2(VI), and i (en)
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