The Central Massachusetts Railroad was a railroad in Massachusetts. The eastern terminus of the line was at North Cambridge Junction where it split off from the Middlesex Central Branch of the Boston and Lowell Railroad in North Cambridge and through which it had access to North Station in Boston. From there, the route ran 98.77 miles west through the modern-day towns of Belmont, Waltham, Weston, Wayland, Sudbury, Hudson, Bolton, Berlin, Clinton, West Boylston, Holden, Rutland, Oakham, Barre, New Braintree, Hardwick, Ware, Palmer, Belchertown, Amherst, and Hadley to its western terminal junction at N. O. Tower in Northampton with the Connecticut River Railroad.