About: CP-122,288

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

CP-122,288 is a drug which acts as a potent and selective agonist for the 5-HT1B, 5-HT1D and 5-HT1F serotonin receptor subtypes. It is a derivative of the migraine medication sumatriptan, but while CP-122,288 is 40,000 times more potent than sumatriptan as an inhibitor of neurogenic inflammation and plasma protein extravasation, it is only twice as potent as a constrictor of blood vessels. In human trials, CP-122,288 was not found to be effective as a treatment for migraine, but its selectivity for neurogenic anti-inflammatory action over vasoconstriction has made it useful for research into the underlying causes of migraine.

Property	Value
dbo:abstract	CP-122,288 is a drug which acts as a potent and selective agonist for the 5-HT1B, 5-HT1D and 5-HT1F serotonin receptor subtypes. It is a derivative of the migraine medication sumatriptan, but while CP-122,288 is 40,000 times more potent than sumatriptan as an inhibitor of neurogenic inflammation and plasma protein extravasation, it is only twice as potent as a constrictor of blood vessels. In human trials, CP-122,288 was not found to be effective as a treatment for migraine, but its selectivity for neurogenic anti-inflammatory action over vasoconstriction has made it useful for research into the underlying causes of migraine. (en)
dbo:casNumber	143321-74-8
dbo:fdaUniiCode	59E9WCT6EM
dbo:pubchem	132552
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dbo:wikiPageWikiLink	dbc:5-HT1B_agonists dbc:Amines dbc:Pyrrolidines dbc:Tryptamines dbr:Eletriptan dbr:CP-135807 dbr:5-MeO-MPMI dbr:Agonist dbc:5-HT1D_agonists dbc:5-HT1F_agonists dbr:Sumatriptan dbr:Migraine dbr:Serotonin_receptor dbr:5-HT1B dbr:5-HT1D dbr:5-HT1F
dbp:c	16 (xsd:integer)
dbp:casNumber	143321 (xsd:integer)
dbp:chemspiderid	117032 (xsd:integer)
dbp:h	23 (xsd:integer)
dbp:iupacName	N-methyl-1-[3--1H-indol-5-yl]methanesulfonamide (en)
dbp:iupharLigand	110 (xsd:integer)
dbp:n	3 (xsd:integer)
dbp:o	2 (xsd:integer)
dbp:pubchem	132552 (xsd:integer)
dbp:s	1 (xsd:integer)
dbp:smiles	CNSCc1ccc2ccC[C@H]3CCCN3C (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	BWQZTHPHLITOOZ-CQSZACIVSA-N (en)
dbp:unii	59000000000 (xsd:decimal)
dbp:width	220 (xsd:integer)
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dct:subject	dbc:5-HT1B_agonists dbc:Amines dbc:Pyrrolidines dbc:Tryptamines dbc:5-HT1D_agonists dbc:5-HT1F_agonists
gold:hypernym	dbr:Drug
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug
rdfs:comment	CP-122,288 is a drug which acts as a potent and selective agonist for the 5-HT1B, 5-HT1D and 5-HT1F serotonin receptor subtypes. It is a derivative of the migraine medication sumatriptan, but while CP-122,288 is 40,000 times more potent than sumatriptan as an inhibitor of neurogenic inflammation and plasma protein extravasation, it is only twice as potent as a constrictor of blood vessels. In human trials, CP-122,288 was not found to be effective as a treatment for migraine, but its selectivity for neurogenic anti-inflammatory action over vasoconstriction has made it useful for research into the underlying causes of migraine. (en)
rdfs:label	CP-122,288 (en)
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