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About: Antifolate

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Antifolates are a class of antimetabolite medications that antagonise (that is, block) the actions of folic acid (vitamin B9). Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently, antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis. Some such as proguanil, pyrimethamine and trimethoprim selectively inhibit folate's actions in microbial organisms such as bacteria, protozoa and fungi. The majority of antifolates work by inhibiting dihydrofolate reductase (DHFR).

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  • مضادات الفولات Antifolates هي أدوية تثبط (أي تمنع) فعالية ونشاط حمض الفوليك (فايتمين B9) هي عبارة عن مركبات عريضة الطيف فعالة ضد الكائنات الحية إيجابية الغرام وسلبيتها . (ar)
  • Antifolates are a class of antimetabolite medications that antagonise (that is, block) the actions of folic acid (vitamin B9). Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently, antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis. Some such as proguanil, pyrimethamine and trimethoprim selectively inhibit folate's actions in microbial organisms such as bacteria, protozoa and fungi. The majority of antifolates work by inhibiting dihydrofolate reductase (DHFR). (en)
  • Antifolato es un tipo de medicamento que impide a las células utilizar ácido fólico para elaborar ADN. También reciben el nombre de antagonista del ácido fólico y antagonista del folato.​ (es)
  • Antifolatoak, folatoaren antagonistak edo azido folikoaren antagonistak azido folikoaren edo B9 bitaminaren antagonistak diren sendagai antimetabolikoak dira; hau da, azido folikoaren funtzioak blokatzen dituztenak. Azido folikoaren funtzio nagusia, gorputzean, zenbait aminoazidoen (serina eta metionina) eta nukleotidoen (timidina eta purina) biosintesian parte hartzen duten izatea da. Beraz, antifolatoek zelula-zatiketa, DNA- zein RNA-sintesi eta -konpontzea eta proteinen sintesia oztopatzen dute. Antifolato batzuk, , pirimetamina eta trimetoprima modu selektiboan inhibitu dezakete mikroorganismoen azido folikoaren eraginak. Antifolato hauetako gehienak edo entzima inhibitzen jarduten dute. (eu)
  • 抗叶酸剂(Antifolate),又称为叶酸拮抗剂,是一类以叶酸(维生素B9)代谢为靶点的制剂,临床上用途包括肿瘤化疗、治疗病原微生物感染(如磺胺类药物)等。叶酸作为一部分酶(如部分)的辅酶,对丝氨酸、蛋氨酸、胸苷,以及嘌呤等分子的生物合成至关重要。因此,叶酸抑制剂能抑制细胞分裂、DNA与RNA合成,以及蛋白合成等生物学过程。目前抗叶酸剂的主要靶点是二氢叶酸还原酶。 低剂量使用抗叶酸剂的不良反应与叶酸缺乏症的症状相似。高叶酸饮食能够部分缓解抗叶酸剂的不良反应。 (zh)
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  • مضادات الفولات Antifolates هي أدوية تثبط (أي تمنع) فعالية ونشاط حمض الفوليك (فايتمين B9) هي عبارة عن مركبات عريضة الطيف فعالة ضد الكائنات الحية إيجابية الغرام وسلبيتها . (ar)
  • Antifolates are a class of antimetabolite medications that antagonise (that is, block) the actions of folic acid (vitamin B9). Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently, antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis. Some such as proguanil, pyrimethamine and trimethoprim selectively inhibit folate's actions in microbial organisms such as bacteria, protozoa and fungi. The majority of antifolates work by inhibiting dihydrofolate reductase (DHFR). (en)
  • Antifolato es un tipo de medicamento que impide a las células utilizar ácido fólico para elaborar ADN. También reciben el nombre de antagonista del ácido fólico y antagonista del folato.​ (es)
  • Antifolatoak, folatoaren antagonistak edo azido folikoaren antagonistak azido folikoaren edo B9 bitaminaren antagonistak diren sendagai antimetabolikoak dira; hau da, azido folikoaren funtzioak blokatzen dituztenak. Azido folikoaren funtzio nagusia, gorputzean, zenbait aminoazidoen (serina eta metionina) eta nukleotidoen (timidina eta purina) biosintesian parte hartzen duten izatea da. Beraz, antifolatoek zelula-zatiketa, DNA- zein RNA-sintesi eta -konpontzea eta proteinen sintesia oztopatzen dute. Antifolato batzuk, , pirimetamina eta trimetoprima modu selektiboan inhibitu dezakete mikroorganismoen azido folikoaren eraginak. Antifolato hauetako gehienak edo entzima inhibitzen jarduten dute. (eu)
  • 抗叶酸剂(Antifolate),又称为叶酸拮抗剂,是一类以叶酸(维生素B9)代谢为靶点的制剂,临床上用途包括肿瘤化疗、治疗病原微生物感染(如磺胺类药物)等。叶酸作为一部分酶(如部分)的辅酶,对丝氨酸、蛋氨酸、胸苷,以及嘌呤等分子的生物合成至关重要。因此,叶酸抑制剂能抑制细胞分裂、DNA与RNA合成,以及蛋白合成等生物学过程。目前抗叶酸剂的主要靶点是二氢叶酸还原酶。 低剂量使用抗叶酸剂的不良反应与叶酸缺乏症的症状相似。高叶酸饮食能够部分缓解抗叶酸剂的不良反应。 (zh)
rdfs:label
  • مضاد الفولات (ar)
  • Antifolate (en)
  • Antifolato (es)
  • Antifolato (eu)
  • 抗叶酸剂 (zh)
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