Prostaglandinski E2 receptor

Prostaglandinski E receptor 2
Prostaglandinski E receptor 2
Identifikatori
Simboli	PTGER2; EP2
Vanjski ID	OMIM: 176804 MGI: 97794 HomoloGene: 739 IUPHAR: EP2 GeneCards: PTGER2 Gene
Ontologija gena
Molekularna funkcija	• aktivnost prostaglandinskog E receptora;
Celularna komponenta	• ćelijska membrana; • integralno sa ćelijskom membranom;
Biološki proces	• signalni put G-protein spregnutog receptora; • signalni put adenilat ciklazom aktiviranog G-protein spregnutog receptora; • respons na lipopolisaharid;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	5732
Ensembl	ENSG00000125384
UniProt	P43116
RefSeq (mRNA)	NM_000956.3
RefSeq (protein)	NP_000947.2
Lokacija (UCSC)	Chr 14:; 52.78 - 52.8 Mb
PubMed pretraga	[1]

Prostaglandinski E2 receptor (EP₂) je prostaglandinski receptor za prostaglandin E2. On je kodiran ljudskim genom PTGER2.^[1]

On je povezan sa aspirinom indukovanom astmom.^[2]

Mehanizam

Ovaj protein je G protein spregnuti receptor, koji aktivira G protein G_s.^[3]

Reference

^ „Entrez Gene: PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa”.
^ Jinnai N; Sakagami T; Sekigawa T; et al. (2004). „Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach”. Hum. Mol. Genet. 13 (24): 3203—17. PMID 15496426. doi:10.1093/hmg/ddh332.
^ Invitrogen Online Ordering: Prostanoid Receptor PTGER2 Assays^{[мртва веза]}

Literatura

Duncan AM; Anderson LL; Funk CD; et al. (1995). „Chromosomal localization of the human prostanoid receptor gene family.”. Genomics. 25 (3): 740—2. PMID 7759114. doi:10.1016/0888-7543(95)80022-E.
Regan JW; Bailey TJ; Pepperl DJ; et al. (1994). „Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype.”. Mol. Pharmacol. 46 (2): 213—20. PMID 8078484.
Bastien L; Sawyer N; Grygorczyk R; et al. (1994). „Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype.”. J. Biol. Chem. 269 (16): 11873—7. PMID 8163486.
An S, Yang J, Xia M, Goetzl EJ (1994). „Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2.”. Biochem. Biophys. Res. Commun. 197 (1): 263—70. PMID 8250933. doi:10.1006/bbrc.1993.2470.
Stillman BA, Breyer MD, Breyer RM (1999). „Importance of the extracellular domain for prostaglandin EP(2) receptor function.”. Mol. Pharmacol. 56 (3): 545—51. PMID 10462542.
Smock SL; Pan LC; Castleberry TA; et al. (1999). „Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E(2) receptor EP2 subtype.”. Gene. 237 (2): 393—402. PMID 10521663. doi:10.1016/S0378-1119(99)00323-6.
Desai S, April H, Nwaneshiudu C, Ashby B (2001). „Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration.”. Mol. Pharmacol. 58 (6): 1279—86. PMID 11093764.
Duckworth N, Marshall K, Clayton JK (2002). „An investigation of the effect of the prostaglandin EP2 receptor agonist, butaprost, on the human isolated myometrium from pregnant and non-pregnant women.”. J. Endocrinol. 172 (2): 263—9. PMID 11834444. doi:10.1677/joe.0.1720263.
Kyveris A, Maruscak E, Senchyna M (2002). „Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR.”. Mol. Vis. 8: 51—8. PMID 11951086.
Takafuji VA, Evans A, Lynch KR, Roche JK (2003). „PGE(2) receptors and synthesis in human gastric mucosa: perturbation in cancer.”. Prostaglandins Leukot. Essent. Fatty Acids. 66 (1): 71—81. PMID 12051958. doi:10.1054/plef.2001.0299.
Scandella E; Men Y; Gillessen S; et al. (2002). „Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells.”. Blood. 100 (4): 1354—61. PMID 12149218. doi:10.1182/blood-2001-11-0017.
Okuyama T; Ishihara S; Sato H; et al. (2002). „Activation of prostaglandin E2-receptor EP2 and EP4 pathways induces growth inhibition in human gastric carcinoma cell lines.”. J. Lab. Clin. Med. 140 (2): 92—102. PMID 12228765.
Konger RL; Scott GA; Landt Y; et al. (2003). „Loss of the EP2 prostaglandin E2 receptor in immortalized human keratinocytes results in increased invasiveness and decreased paxillin expression.”. Am. J. Pathol. 161 (6): 2065—78. PMC 1850902  . PMID 12466123. doi:10.1016/S0002-9440(10)64485-9.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241  . PMID 12477932. doi:10.1073/pnas.242603899.
Abulencia JP; Gaspard R; Healy ZR; et al. (2003). „Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells”. J. Biol. Chem. 278 (31): 28388—94. PMID 12743126. doi:10.1074/jbc.M301378200.
Richards JA, Brueggemeier RW (2003). „Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes”. J. Clin. Endocrinol. Metab. 88 (6): 2810—6. PMID 12788892. doi:10.1210/jc.2002-021475.
Sun HS; Hsiao KY; Hsu CC; et al. (2003). „Transactivation of steroidogenic acute regulatory protein in human endometriotic stromalcells is mediated by the prostaglandin EP2 receptor”. Endocrinology. 144 (9): 3934—42. PMID 12933667. doi:10.1210/en.2003-0289.
Bradbury DA; Newton R; Zhu YM; et al. (2004). „Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, E-prostanoid 2 (EP2), and EP4 receptors”. J. Biol. Chem. 278 (50): 49954—64. PMID 14517215. doi:10.1074/jbc.M307964200.
Moreland RB; Kim N; Nehra A; et al. (2004). „Functional prostaglandin E (EP) receptors in human penile corpus cavernosum”. Int. J. Impot. Res. 15 (5): 362—8. PMID 14562138. doi:10.1038/sj.ijir.3901042.
Sugimoto Y; Nakato T; Kita A; et al. (2004). „A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors”. J. Biol. Chem. 279 (12): 11016—26. PMID 14699136. doi:10.1074/jbc.M307404200.

Vidi još

Eikozanoidni receptor

Spoljašnje veze

„Prostanoid Receptor: EP₂”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.

[entrez-1] „Entrez Gene: PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa”.

[pmid15496426-2] Jinnai N; Sakagami T; Sekigawa T; et al. (2004). „Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach”. Hum. Mol. Genet. 13 (24): 3203—17. PMID 15496426. doi:10.1093/hmg/ddh332.

[3] Invitrogen Online Ordering: Prostanoid Receptor PTGER2 Assays^{[мртва веза]}

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