LY-487,379

LY-487,379
IUPAC ime
	N-(4-(2-metoksifenoksi)fenil)- N-(2,2,2-trifluoroetilsulfonil)pirid- 3-ilmetilamin
Identifikatori
ATC kod	none
PubChem	CID 9825084
IUPHAR/BPS	1402
ChEMBL	CHEMBL108939
Hemijski podaci
Formula	C21H19F3N2O4S
Molarna masa	452,446 g/mol
	SMILES c3ncccc3CN(S(=O)(=O)CC(F)(F)F)c2ccc(cc2)Oc1ccccc1OC; ;

LY-487,379 je lek koji se koristi u naučnim istraživanjima. On deluje kao selektivni pozitivni alosterni modulator za metabotropni glutamatni receptor grupe II mGluR₂.^[1] On se koristio za studiranje strukture i funkcije ovog tipa receptor,^[2]^[3] i LY-487,379 se zajedno sa drugim mGluR_2/3 agonistima i pozitivnim modulatorima istražuje kao mogući antipsihotik i anksiolitik.^[4]^[5]^[6]^[7]

Reference

^ Johnson, M. P.; Baez, M.; Jagdmann Jr, G. E.; Britton, T. C.; Large, T. H.; Callagaro, D. O.; Tizzano, J. P.; Monn, J. A.; et al. (2003). „Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor: Synthesis and Subtype Selectivity ofN-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2− trifluoroethylsulfonyl)pyrid-3-ylmethylamine”. Journal of Medicinal Chemistry. 46 (15): 3189—3192. PMID 12852748. doi:10.1021/jm034015u.
^ HSchaffhauser, H.; Rowe, B. A.; Morales, S.; Chavez-noriega, L. E.; Yin, R.; Jachec, C.; Rao, S. P.; Bain, G.; et al. (2003). „Pharmacological Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2”. Molecular Pharmacology. 64 (4): 798—810. PMID 14500736. doi:10.1124/mol.64.4.798.
^ Poisik, O.; Raju, D. V.; Verreault, M.; Rodriguez, A.; Abeniyi, O. A.; Conn, P. J.; Smith, Y. (2005). „Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus”. Neuropharmacology. 49: 57—50. PMID 15993439. doi:10.1016/j.neuropharm.2005.03.006.
^ Galici, R.; Echemendia, N. G.; Rodriguez, A. L.; Conn, P. J. (2005). „A Selective Allosteric Potentiator of Metabotropic Glutamate (mGlu) 2 Receptors Has Effects Similar to an Orthosteric mGlu2/3 Receptor Agonist in Mouse Models Predictive of Antipsychotic Activity”. Journal of Pharmacology and Experimental Therapeutics. 315 (3): 1181—7. PMID 16123306. doi:10.1124/jpet.105.091074.
^ Marino; Conn, P. (2006). „Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors”. Current Opinion in Pharmacology. 6 (1): 98—102. PMID 16368268. doi:10.1016/j.coph.2005.09.006.
^ Harich; Gross, G.; Bespalov, A. (2007). „Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment”. Psychopharmacology. 192 (4): 511—519. PMID 17318501. doi:10.1007/s00213-007-0742-y.
^ Dillon Ripley (1958). „Extinct and Vanishing Birds of the World”. The Auk. 75 (4): 480—482. JSTOR 4082117. PMID 190790739.

Vidi još

Spoljašnje veze

[1] Johnson, M. P.; Baez, M.; Jagdmann Jr, G. E.; Britton, T. C.; Large, T. H.; Callagaro, D. O.; Tizzano, J. P.; Monn, J. A.; et al. (2003). „Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor: Synthesis and Subtype Selectivity ofN-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2− trifluoroethylsulfonyl)pyrid-3-ylmethylamine”. Journal of Medicinal Chemistry. 46 (15): 3189—3192. PMID 12852748. doi:10.1021/jm034015u.

[2] HSchaffhauser, H.; Rowe, B. A.; Morales, S.; Chavez-noriega, L. E.; Yin, R.; Jachec, C.; Rao, S. P.; Bain, G.; et al. (2003). „Pharmacological Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2”. Molecular Pharmacology. 64 (4): 798—810. PMID 14500736. doi:10.1124/mol.64.4.798.

[3] Poisik, O.; Raju, D. V.; Verreault, M.; Rodriguez, A.; Abeniyi, O. A.; Conn, P. J.; Smith, Y. (2005). „Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus”. Neuropharmacology. 49: 57—50. PMID 15993439. doi:10.1016/j.neuropharm.2005.03.006.

[4] Galici, R.; Echemendia, N. G.; Rodriguez, A. L.; Conn, P. J. (2005). „A Selective Allosteric Potentiator of Metabotropic Glutamate (mGlu) 2 Receptors Has Effects Similar to an Orthosteric mGlu2/3 Receptor Agonist in Mouse Models Predictive of Antipsychotic Activity”. Journal of Pharmacology and Experimental Therapeutics. 315 (3): 1181—7. PMID 16123306. doi:10.1124/jpet.105.091074.

[5] Marino; Conn, P. (2006). „Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors”. Current Opinion in Pharmacology. 6 (1): 98—102. PMID 16368268. doi:10.1016/j.coph.2005.09.006.

[6] Harich; Gross, G.; Bespalov, A. (2007). „Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment”. Psychopharmacology. 192 (4): 511—519. PMID 17318501. doi:10.1007/s00213-007-0742-y.

[7] Dillon Ripley (1958). „Extinct and Vanishing Birds of the World”. The Auk. 75 (4): 480—482. JSTOR 4082117. PMID 190790739.

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