Beta-laktamaza
Beta-laktamaza (EC 3.5.2.6, penicilinaza, cefalosporinaza, neutrapen, penicilinska beta-laktamaza, eksopenicilinaza, ampicillinaza, penicilin amido-beta-laktamhidrolaza, penicilinaza I, II, beta-laktamaza I-III, beta-laktamaza A, B, C, beta-laktamaza AME I, cefalosporin-beta-laktamaza) je enzim sa sistematskim imenom beta-laktam hidrolaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Beta-laktamaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Metallo-beta-laktamaza L1 homotetramer, Stenotrophomonas | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.5.2.6 | ||||||||
| CAS broj | 9073-60-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- beta-laktam + H2O supstituisana beta-aminokiselina
Ova grupa enzima ima promenljivu specifičnost hidrolize beta-laktama.
Reference
уреди- ^ Citri, N. (1971). „Penicillinase and other β-lactamases”. Ур.: Boyer, P.D. The Enzymes. 4 (3rd изд.). New York: Academic Press. стр. 23—46.
- ^ Hennessey, T.D. & Richmond, M.H. (1968). „The purification and some properties of a β-lactamase (cephalosporinase) synthesized by Enterobacter cloacae”. Biochem. J. 109: 469—473. PMID 5685878.
- ^ Kuwabara, S. (1970). „Purification and properties of two extracellular β-lactamases from Bacillus cereus 569-H”. Biochem. J. 118: 457—465. PMID 4990588.
- ^ Pollock, M.R. (1960). „Penicillinase”. Ур.: Boyer, P.D., Lardy, H.; Myrb; auml; ck, K. The Enzymes. 4 (2nd изд.). New York: Academic Press. стр. 269—278.
- ^ Pollock, M.R., Torriani, A.-M. and Tridgell, E.G. (1956). „Crystalline bacterial penicillinase”. Biochem. J. 62: 387—391. PMID 13303985.
- ^ Ross, G.W. & Boulton, M.G. (1973). „Purification of β-lactamases on QAE-sephadex”. Biochim. Biophys. Acta. 309: 430—439. PMID 4731970.
Литература
уреди- Pollock, M.R. (1960). „Penicillinase”. Ур.: Boyer, P.D., Lardy, H.; Myrb; auml; ck, K. The Enzymes. 4 (2nd изд.). New York: Academic Press. стр. 269—278.
- Citri, N. (1971). „Penicillinase and other β-lactamases”. Ур.: Boyer, P.D. The Enzymes. 4 (3rd изд.). New York: Academic Press. стр. 23—46.
Spoljašnje veze
уреди- Beta-lactamase на US National Library of Medicine Medical Subject Headings (MeSH)