Kaspaza
Kaspaze (cistein-aspartičke proteaze) su familija cistenskih proteaza koje imaju esencijalne uloge u apoptozi (programiranoj ćelijskoj smrti), nekrozi, u inflamaciji.[2]
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| Struktura interleukin-1 beta-konvertujućeg enzima.[1] | |||||||||
| Identifikatori | |||||||||
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| Simbol | Peptidase_C14 | ||||||||
| Pfam | PF00656 | ||||||||
| Pfam klan | CL0093 | ||||||||
| InterPro | IPR002398 | ||||||||
| PROSITE | PS50208 | ||||||||
| MEROPS | C14 | ||||||||
| SCOP | 1ice | ||||||||
| Superfamilija | 1ice | ||||||||
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Pojedine kaspaze su neophodne u imunskom sistemu za maturaciju limfocita. Neuspeh apoptoze je jedan od glavnih faktora koji doprinose razvoju tumora i autoimunskih oboljenja. Ta činjenica zajedno neželjenom apoptozom do koje dolazi pri ishemiji ili kod Alchajmerove bolesti, je stimulisala interest u kaspaze kao potencijalne terapeutske mete još od vremena njihovog otkrića tokom sredine 1990-tih.
Reference
uredi- ↑ Wilson KP, Black JA, Thomson JA, et al. (July 1994). „Structure and mechanism of interleukin-1 beta converting enzyme”. Nature 370 (6487): 270–5. DOI:10.1038/370270a0. PMID 8035875.
- ↑ Alnemri ES, Emad S; et al. (1996). „Human ICE/CED-3 Protease Nomenclature”. Cell 87 (2): 171. DOI:10.1016/S0092-8674(00)81334-3. PMID 8861900. Pristupljeno 2011-03-06.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Povezano
urediSpoljašnje veze
uredi- Apoptosis Video Arhivirano 2007-06-30 na Wayback Machine-u Demonstrates a model of a caspase cascade as it occurs in vivo.
- The Mechanisms of Apoptosis Arhivirano 2018-03-09 na Wayback Machine-u Kimball's Biology Pages. Simple explanation of the mechanisms of apoptosis triggered by internal signals (bcl-2), along the caspase-9, caspase-3 and caspase-7 pathway; and by external signals (FAS and TNF), along the caspase 8 pathway. Accessed 25 March 2007.
- MeSH Caspases