The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity

…, F Zhao, S He, L Yang, M Zhang, F Nan, J Li… - Nature …, 2017 - nature.com
Obesity is associated with metabolic inflammation and endoplasmic reticulum (ER) stress,
both of which promote metabolic disease progression. Adipose tissue macrophages (ATMs) …

Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts Endoplasmic Reticulum Stress-induced …

…, Y Zhang, Y Liu, Y Deng, B Shan, J Liu, H Li… - Journal of Biological …, 2014 - ASBMB
Endoplasmic reticulum (ER) stress activates the adaptive unfolded protein response (UPR)
and represents a critical mechanism that underlies metabolic dysfunctions. Fibroblast growth …

Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s–PPARα axis signalling

…, T Mao, Y Qiu, Y Zhou, S Jiang, W Jia, J Li, J Li… - Nature …, 2014 - nature.com
Although the mammalian IRE1α-XBP1 branch of the cellular unfolded protein response has
been implicated in glucose and lipid metabolism, the exact metabolic role of IRE1α …

Experimental investigation and prediction of elastic modulus of ultra-high performance concrete (UHPC) based on its composition

X Ouyang, C Shi, Z Wu, K Li, B Shan, J Shi - Cement and Concrete …, 2020 - Elsevier
Scientific design of the composition of UHPC is important in achieving desired elastic modulus
and prediction. In this paper, an analytical model based on composition through using a …

Adiponectin preserves metabolic fitness during aging

N Li, S Zhao, Z Zhang, Y Zhu, CM Gliniak, L Vishvanath… - Elife, 2021 - elifesciences.org
Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin
sensitivity. Clinical studies have suggested a positive association of circulating adiponectin …

The structure of engineering project evaluation system: Model and analysis

S Li, Q Xiong - Systems Engineering Procedia, 2011 - Elsevier
From the system theory perspective, the paper constructs a structure model of engineering
project evaluation system that provides an analysis framework to project evaluation. The …

Thermal interface materials based on vertically aligned carbon nanotube arrays: a review

G Yuan, H Li, B Shan, J Liu - Micro and Nanosystems, 2019 - ingentaconnect.com
As the feature size of integrated circuit devices is shrinking to sub-7 nm node, the chip power
dissipation significantly increases and mainly converted to the heat. Vertically Aligned …

ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes

…, A Truong, B Shan, L Vishvanath, L Li… - Genes & …, 2021 - genesdev.cshlp.org
Energy-storing white adipocytes maintain their identity by suppressing the energy-burning
thermogenic gene program of brown and beige adipocytes. Here, we reveal that the protein–…

miR-103-3p targets Ndel1 to regulate neural stem cell proliferation and differentiation

W Li, SS Wang, BQ Shan, JB Qin… - Neural regeneration …, 2022 - journals.lww.com
The regulation of adult neural stem cells (NSCs) is critical for lifelong neurogenesis. MicroRNAs
(miRNAs) are a type of small, endogenous RNAs that regulate gene expression post-…

The ER stress sensor inositol-requiring enzyme 1α in Kupffer cells promotes hepatic ischemia-reperfusion injury

J Cai, X Zhang, P Chen, Y Li, S Liu, Q Liu… - Journal of Biological …, 2022 - ASBMB
Hepatic ischemia/reperfusion (I/R) injury is an inflammation-mediated process arising from
ischemia/reperfusion-elicited stress in multiple cell types, causing liver damage during …