The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity
…, F Zhao, S He, L Yang, M Zhang, F Nan, J Li… - Nature …, 2017 - nature.com
Obesity is associated with metabolic inflammation and endoplasmic reticulum (ER) stress,
both of which promote metabolic disease progression. Adipose tissue macrophages (ATMs) …
both of which promote metabolic disease progression. Adipose tissue macrophages (ATMs) …
Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts Endoplasmic Reticulum Stress-induced …
Endoplasmic reticulum (ER) stress activates the adaptive unfolded protein response (UPR)
and represents a critical mechanism that underlies metabolic dysfunctions. Fibroblast growth …
and represents a critical mechanism that underlies metabolic dysfunctions. Fibroblast growth …
Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s–PPARα axis signalling
…, T Mao, Y Qiu, Y Zhou, S Jiang, W Jia, J Li, J Li… - Nature …, 2014 - nature.com
Although the mammalian IRE1α-XBP1 branch of the cellular unfolded protein response has
been implicated in glucose and lipid metabolism, the exact metabolic role of IRE1α …
been implicated in glucose and lipid metabolism, the exact metabolic role of IRE1α …
Experimental investigation and prediction of elastic modulus of ultra-high performance concrete (UHPC) based on its composition
Scientific design of the composition of UHPC is important in achieving desired elastic modulus
and prediction. In this paper, an analytical model based on composition through using a …
and prediction. In this paper, an analytical model based on composition through using a …
Adiponectin preserves metabolic fitness during aging
Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin
sensitivity. Clinical studies have suggested a positive association of circulating adiponectin …
sensitivity. Clinical studies have suggested a positive association of circulating adiponectin …
The structure of engineering project evaluation system: Model and analysis
S Li, Q Xiong - Systems Engineering Procedia, 2011 - Elsevier
From the system theory perspective, the paper constructs a structure model of engineering
project evaluation system that provides an analysis framework to project evaluation. The …
project evaluation system that provides an analysis framework to project evaluation. The …
Thermal interface materials based on vertically aligned carbon nanotube arrays: a review
G Yuan, H Li, B Shan, J Liu - Micro and Nanosystems, 2019 - ingentaconnect.com
As the feature size of integrated circuit devices is shrinking to sub-7 nm node, the chip power
dissipation significantly increases and mainly converted to the heat. Vertically Aligned …
dissipation significantly increases and mainly converted to the heat. Vertically Aligned …
ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes
…, A Truong, B Shan, L Vishvanath, L Li… - Genes & …, 2021 - genesdev.cshlp.org
Energy-storing white adipocytes maintain their identity by suppressing the energy-burning
thermogenic gene program of brown and beige adipocytes. Here, we reveal that the protein–…
thermogenic gene program of brown and beige adipocytes. Here, we reveal that the protein–…
miR-103-3p targets Ndel1 to regulate neural stem cell proliferation and differentiation
W Li, SS Wang, BQ Shan, JB Qin… - Neural regeneration …, 2022 - journals.lww.com
The regulation of adult neural stem cells (NSCs) is critical for lifelong neurogenesis. MicroRNAs
(miRNAs) are a type of small, endogenous RNAs that regulate gene expression post-…
(miRNAs) are a type of small, endogenous RNAs that regulate gene expression post-…
The ER stress sensor inositol-requiring enzyme 1α in Kupffer cells promotes hepatic ischemia-reperfusion injury
J Cai, X Zhang, P Chen, Y Li, S Liu, Q Liu… - Journal of Biological …, 2022 - ASBMB
Hepatic ischemia/reperfusion (I/R) injury is an inflammation-mediated process arising from
ischemia/reperfusion-elicited stress in multiple cell types, causing liver damage during …
ischemia/reperfusion-elicited stress in multiple cell types, causing liver damage during …