Although studies of Saccharomyces cerevisiae have provided many insights into mutagenesis
and DNA repair, most of this work has focused on a few laboratory strains. Much less is …

The identification and validation of gene–gene interactions is a major challenge in human
studies. Here, we explore an approach for studying epistasis in humans using a Drosophila …

Canalization involves mutational robustness, the lack of phenotypic change as a result of
genetic mutations. Given the large divergence in phenotype across species, understanding the …

Studying the genetic and molecular characteristics of brewing yeast strains is crucial for
understanding their domestication history and adaptations accumulated over time in …

The evolution of canalized traits is a central question in evolutionary biology. Natural variation
in highly conserved traits can provide clues about their evolutionary potential. Here we …

Throughout the COVID-19 pandemic, China effectively contained the virus, resulting in
increased public trust in the government. Mobile government (mGovernment) applications (apps) …

Expansion of sequencing efforts to include thousands of genomes is providing a fundamental
resource for determining the genetic diversity that exists in a population. Now, high-…

Under the effect of strong genetic drift, it is highly probable to observe gene fixation or gene
loss in a population, shown by singular peaks on a potential landscape. The genetic drift-…

Understanding the generation of mutations is fundamental to understanding evolution and
genetic disease; however, the rarity of such events makes experimentally identifying them …

Adaptive landscape, proposed by Sewall Wright, has provided a conceptual framework to
describe dynamical behaviours. However, it is still a challenge to explicitly construct such a …