Obesity and its metabolic consequences are a major public health concern worldwide.
Obesity is associated with overactivity of the endocannabinoid system, which is involved in the …

The endogenous cannabinoids bind to and activate two G protein-coupled receptors, the
predominantly central cannabinoid receptor type 1 (CB1) and peripheral cannabinoid receptor …

Type 2 diabetes mellitus (T2DM) progresses from compensated insulin resistance to beta
cell failure resulting in uncompensated hyperglycemia, a process replicated in the Zucker …

Obesity-related leptin resistance manifests in loss of leptin's ability to reduce appetite and
increase energy expenditure. Obesity is also associated with increased activity of the …

Major depression is associated with low bone mass and increased incidence of osteoporotic
fractures. However, causality between depression and bone loss has not been established. …

We have recently reported that in bone the cannabinoid CB1 receptor is present in sympathetic
terminals. Here we show that traumatic brain injury (TBI), which in humans enhances …

Endocannabinoids are lipid mediators of the same cannabinoid (CB) receptors that mediate
the effects of marijuana. The endocannabinoid system (ECS) consists of CB receptors, …

Poly(ethylene oxide)-b-poly(ε-caprolactone) (PEO-b-PCL) block copolymers self-assemble
into micelles in aqueous solution. We have examined whether these micelles can internalize …

BACKGROUND & AIMS: Obesity-related insulin resistance contributes to cardiovascular
disease. Cannabinoid receptor-1 (CB 1 ) blockade improves insulin sensitivity in obese animals …

The CB1 cannabinoid receptor has been implicated in the regulation of bone remodeling and
bone mass. A high bone mass (HBM) phenotype was reported in CB1-null mice generated …