Recording of glutamate-activated currents in membrane patches was combined with RT-PCR-mediated
AMPA receptor (AMPAR) subunit mRNA analysis in single identified cells of rat …

AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor channels mediate
the fast component of excitatory postsynaptic currents in the central nervous system. Site-…

Abstract Analysis of presynaptic determinants of synaptic strength has been difficult at cortical
synapses, mainly due to the lack of direct access to presynaptic elements. Here we report …

Invasive cell migration through tissue barriers requires pericellular remodelling of extracellular
matrix (ECM) executed by cell-surface proteases, particularly membrane-type-1 matrix …

Networks of GABAergic interneurons are of critical importance for the generation of gamma
frequency oscillations in the brain. To examine the underlying synaptic mechanisms, we …

Antiplatelet treatment is of fundamental importance in combatting functions/dysfunction of
platelets in the pathogenesis of cardiovascular and inflammatory diseases. Dysfunction of …

Action potentials in nonmyelinated axons are considered to contribute substantially to
activity-dependent brain metabolism. Here we show that fast Na + current decay and delayed K + …

Glutamatergic transmission at a principal neuron–interneuron synapse was investigated by
dual whole-cell patch-clamp recording in rat hippocampal slices combined with …

Rigorous analysis of synaptic transmission in the central nervous system requires access to
presynaptic terminals. However, cortical terminals have been largely inaccessible to …

Increased platelet adhesion or aggregation are key events in the pathogenesis of cardiovascular
diseases. Exact determination of the platelet activation state is essential to recognize, …