Profils utilisateurs correspondant à "Heng Li"
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Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM
H Li - arXiv preprint arXiv:1303.3997, 2013 - arxiv.org
BWA-MEM is a new alignment algorithm for aligning sequence reads or long query sequences
against a large reference genome such as human. It automatically chooses between …
against a large reference genome such as human. It automatically chooses between …
Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving
…, KY Tseng, JL Uejima, JM Reimers, LJ Heng… - Nature, 2008 - nature.com
Relapse to cocaine use after prolonged abstinence is an important clinical problem. This
relapse is often induced by exposure to cues associated with cocaine use. To account for the …
relapse is often induced by exposure to cues associated with cocaine use. To account for the …
A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data
H Li - Bioinformatics, 2011 - academic.oup.com
Motivation: Most existing methods for DNA sequence analysis rely on accurate sequences
or genotypes. However, in applications of the next-generation sequencing (NGS), accurate …
or genotypes. However, in applications of the next-generation sequencing (NGS), accurate …
Minimap and miniasm: fast mapping and de novo assembly for noisy long sequences
H Li - Bioinformatics, 2016 - academic.oup.com
Motivation: Single Molecule Real-Time (SMRT) sequencing technology and Oxford
Nanopore technologies (ONT) produce reads over 10 kb in length, which have enabled high-quality …
Nanopore technologies (ONT) produce reads over 10 kb in length, which have enabled high-quality …
Tabix: fast retrieval of sequence features from generic TAB-delimited files
H Li - Bioinformatics, 2011 - academic.oup.com
Tabix is the first generic tool that indexes position sorted files in TAB-delimited formats such
as GFF, BED, PSL, SAM and SQL export, and quickly retrieves features overlapping …
as GFF, BED, PSL, SAM and SQL export, and quickly retrieves features overlapping …
Toward better understanding of artifacts in variant calling from high-coverage samples
H Li - Bioinformatics, 2014 - academic.oup.com
Motivation: Whole-genome high-coverage sequencing has been widely used for personal
and cancer genomics as well as in various research areas. However, in the lack of an …
and cancer genomics as well as in various research areas. However, in the lack of an …
EnsemblCompara GeneTrees: Complete, duplication-aware phylogenetic trees in vertebrates
We have developed a comprehensive gene orientated phylogenetic resource, EnsemblCompara
GeneTrees, based on a computational pipeline to handle clustering, multiple alignment…
GeneTrees, based on a computational pipeline to handle clustering, multiple alignment…
Automatic pixel‐level crack detection and measurement using fully convolutional network
The spatial characteristics of cracks are significant indicators to assess and evaluate the
health of existing buildings and infrastructures. However, the current manual crack description …
health of existing buildings and infrastructures. However, the current manual crack description …
PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and-independent mechanisms
DJ Freeman, AG Li, G Wei, HH Li, N Kertesz, R Lesche… - Cancer cell, 2003 - cell.com
We show in this study that PTEN regulates p53 protein levels and transcriptional activity
through both phosphatase-dependent and -independent mechanisms. The onset of tumor …
through both phosphatase-dependent and -independent mechanisms. The onset of tumor …
A Draft Sequence for the Genome of the Domesticated Silkworm (Bombyx mori)
We report a draft sequence for the genome of the domesticated silkworm (Bombyx mori),
covering 90.9% of all known silkworm genes. Our estimated gene count is 18,510, which …
covering 90.9% of all known silkworm genes. Our estimated gene count is 18,510, which …